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Sleep-inducing Blood Metabolites Associated With CSF Amyloid Burden
Blood concentrations of fatty molecules which induce sleep were higher in those participants in the study with amyloid in the brain, the peptide used to diagnose Alzheimer’s disease.
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CRISPR Helps Decipher a Congenital Liver Disease
Researchers describe a new experimental model of Congenital hepatic fibrosis (CHF), which allowed them to uncover molecular players that may contribute to the illness.
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Altered Tau Levels in Spinal Fluid of Athletes After Multiple Concussions
In a group of 22 former professional athletes who experienced multiple concussions, approximately half the group had higher than normal concentrations of tau in their cerebrospinal fluid.
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Targeting Ribosome Biogenesis as a Novel Approach for Multi-Stage Cancer Treatment
Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced.
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Regeneration of Severely Damaged Lungs a Transplant Game-changer
Columbia Engineering and Vanderbilt researchers are first to demonstrate in a clinically relevant model that severely damaged lungs can be regenerated to meet transplantation criteria, which could lead to more lungs available for transplant.
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Bacteria’s Secret Signaling System Opens Doors for Antibiotic Therapy
Researchers have discovered a previously unknown signaling pathway that regulates surface proteins on bacteria that can lead to new targets for antibiotics.
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Eye’s Vulnerability to Macular Degeneration Revealed
Scientists have found significant differences in the shape and biology of the same type of cell taken from different parts of the retina. The results could help explain why the macular region of the eye is more susceptible to disease than the peripheral retina and reveals a protective mechanism that may be disrupted in disease.
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Reduced Fibromyalgia Pain Scores in People Treated for Insulin Resistance
A retrospective review of people with fibromyalgia revealed insights into a possible pathogenic relationship between fibromyalgia and insulin resistance. Those who had undergone treatment with metformin, a medicine used to treat type 2 diabetes, reported dramatic improvements of their pain after treatment.
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Susceptible Cell Types in Hypoxia Identified
Low oxygen levels are a well-known cause of brain injury in premature babies. Until now, the mechanism by which low oxygen hurts the developing human brain has been unclear.
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Single Gene Mutation Tells Story of Novel Immunodeficiency Disease
A new immunodeficiency disease caused by a novel genetic mutation has been identified by researchers.
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