AI-driven Imaging Research Makes Diagnosing Disease Easier
A recent advancement in microscope imaging technology at the University of Waterloo could soon make diagnosing disease more accessible and affordable.
The advancement, developed by Waterloo researchers Farnoud Kazemzadeh and Alexander Wong, has led to a new form of spectral light-fusion microscope for capturing lightfield images in full-colour. Full-colour images are required in pathology as it enables the microscope user to analyze the behaviour and interactions of different organisms at a scale that much larger than traditional microscopes.
Pathology is a medical specialty that focuses on the diagnosis of disease based on laboratory analysis of bodily fluids and tissues.
The several-hundred-dollar microscope has no lens, and uses artificial intelligence and mathematical models of light to develop 3D images at a large scale. It’s a process that currently requires a technician to “stitch” together multiple images from traditional microscope images to get the same effect, and requires a machine that costs several hundred thousand dollars.
“In medicine, we know that pathology is the gold standard in helping to analyze and diagnose patients, but that standard is difficult to come by in areas that can’t afford it,” said Wong, an associate professor of Engineering at Waterloo and Canada Research Chair in Medical Imaging. “This technology has the potential to make pathology labs more affordable for communities who currently don’t have access to conventional equipment.”
The current spectral light-fusion microscope represents the second-generation of technology that he patented last year with Kazemzadeh.
The microscope captures light fields and allows for 3D images that are approximately 100-times larger than the 2D images captured by more traditional microscopes.
“Currently, the technology required to operate a pathology lab is quite expensive and is largely restricted to places such as Europe and North America, which can afford them,” said Kazemzadeh, an adjunct professor of Systems Design Engineering at Waterloo. “It would be interesting to see what a more affordable, mobile pathology lab could achieve.”
Details of the first-generation microscope invented by Kazemzadeh and Wong were published last year in Nature Scientific Reports.
This article has been republished from materials provided by the University of Waterloo. Note: material may have been edited for length and content. For further information, please contact the cited source.
Study Reveals How MRSA Infection Compromises Lymphatic FunctionNews
Infections of the skin or other soft tissues with the hard-to-treat MRSA bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. Investigators describe how MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes in mouse models, which may contribute to the frequent recurrences of MRSA infection experienced by patients.
Researchers Zoom in on DNA Code Being Read in CellsNews
Scientists have unveiled incredible images of how the DNA code is read and interpreted – revealing new detail about one of the fundamental processes of life. The mechanism for reading DNA and decoding it to build proteins for their needs is common to all animals and plants, and is often hijacked by cancer. The discovery of exactly how the molecular mechanism works, could open up new approaches to cancer treatment.READ MORE
"Cell Quake Elastography" Maps Elasticity of Cell ComponentsNews
In somewhat the same way that seismologists use the vibrations of planet Earth to characterize its deep structure, scientists have discovered a way to use vibrations within cells to identify their mechanical properties.READ MORE