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Atomic Structure of Aβ Protein Assemblies Revealed

News   Jun 29, 2020 | Original story from the Institute for Research in Biomedicine

 
Atomic Structure of Aβ Protein Assemblies Revealed

The amyloid precursor protein (APP) is inserted into the cell membrane of neurons. After sequential cleavage by β- and ?-secretases, the Aβ protein (in green) is released. The membrane oligomers are formed by 4 or 8 copies of the Aβ protein. The physicochemical properties of the edges of these oligomers form a path for passage of water and ions (in red) through the membrane, thus disrupting ion cell homeostasis. Credit: Benjamin Bardiaux.

 
 
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