Blood Test Could Help Bowel Cancer Patients Avoid Drug Side-Effects
News Mar 26, 2015
Colorectal, or bowel, cancer is the second biggest cancer killer in Europe. It is most commonly treated with a combination of chemotherapy agents, and outcome can be improved by using additional drugs. However, this multi-drug approach can increase side-effects such as hair loss, low white blood cell count, diarrhoea and damage to the peripheral nervous system.
The team from Manchester counted tumour cells in a patient’s blood sample as a way of predicting who might benefit most.
Professor Caroline Dive, from the Cancer Research UK Manchester Institute at The University of Manchester - part of the Manchester Cancer Research Centre - who jointly led the study, said: “Here in Manchester we are interested in detecting cancer cells that have been shed from a patient’s tumour and are circulating in their blood. In this study we wanted to see if the number of tumour cells in a blood sample could be linked to how well patients respond to intensive chemotherapy.”
The group looked at patients with advanced colorectal cancer who received a four-drug combination treatment. They confirmed that those patients with three or more circulating tumour cells (CTCs) in their blood sample had a lower overall survival, compared with those patients who had fewer than three CTCs. The team also presented data that suggested that patients with a higher CTC count before treatment could benefit more from this more intensive treatment regimen.
Dr Mark Saunders, a Consultant Oncologist from The Christie NHS Foundation Trust, who also led the study, said: “Our initial results suggest that this test could prove useful for patient selection and we should now validate it in further larger trials of new treatments for bowel cancer.”
Dr Matt Krebs, Clinical Senior Lecturer at The University of Manchester and part of the study team, added: “These studies are important for the development of a more personalized treatment approach for cancer patients where patients receive the treatments most likely to benefit them.”
Cancer is one of The University of Manchester’s research beacons - examples of pioneering discoveries, interdisciplinary collaboration and cross-sector partnerships that are tackling some of the biggest questions facing the planet.
Researchers have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer’s disease. If the method is approved for clinical use, the researchers hope eventually to see it used as a diagnostic tool in primary healthcare. This autumn, they will start a trial in primary healthcare to test the technique.