We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Diabetic Skin Model Developed Using 3D Cell Printing
News

Diabetic Skin Model Developed Using 3D Cell Printing

Diabetic Skin Model Developed Using 3D Cell Printing
News

Diabetic Skin Model Developed Using 3D Cell Printing

Credit: Pixabay
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Diabetic Skin Model Developed Using 3D Cell Printing"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The skin, which covers the surface of the human body, is its largest organ. It is the first organ to show changes stemming from organ or physiological activity. It is especially common for diabetic patients to suffer from skin diseases or infections. Recently, a POSTECH research team has succeeded in creating a 3D artificial skin that enables observation of skin diseases of diabetic patients.

A research team led by Professor Dong-Woo Cho and Minjun Ahn of POSTECH's Department of Mechanical Engineering and Professor Byoung Soo Kim of School of Biomedical Convergence Engineering at Pusan National University has successfully produced an in vitro diseased skin model that displays the pathophysiological hallmarks of type 2 diabetes based on 3D cell printing system. These research findings were recently published in Biomaterials, a world-renowned international journal in biomaterials.

Despite continuous research to produce artificial skin with 3D cell printing technology, artificial skin displaying the pathological process present in the native skin has not been reported yet.

Inspired by the interaction between the epidermis and skin cells found in real skin, the research team hypothesized that when normal keratinocytes interact with the dermal layer made of diabetic fibroblasts, they will differentiate into diabetic epidermis. To prove this, diabetic artificial skin with skin wounds based on 3D printing technique was fabricated using each cell.

In this diabetic artificial skin, slow re-epithelialization, a typical feature of diabetic skin, was observed. In addition, when the diabetic fat tissue layer containing blood vessels was added, insulin resistance, adipocyte hypertrophy, pro-inflammatory response, and vascular dysfunction, which are commonly observed in diabetes, were confirmed.

"Through 3D cell printing, we can now observe skin diseases in vitro, without actually experiencing it," remarked the researchers. "We anticipate it to be a way to replace animal models that have been conventionally used to observe skin diseases. It is significant that its applicability as a disease model for new drug development has been proven."

Reference: Kim BS, Ahn M, Cho W-W, Gao G, Jang J, Cho D-W. Engineering of diseased human skin equivalent using 3D cell printing for representing pathophysiological hallmarks of type 2 diabetes in vitro. Biomater. 2021;272:120776. doi:10.1016/j.biomaterials.2021.120776

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement