We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Diagnostic Blood Test Could Help the Fight To Eliminate Malaria
News

Diagnostic Blood Test Could Help the Fight To Eliminate Malaria

Diagnostic Blood Test Could Help the Fight To Eliminate Malaria
News

Diagnostic Blood Test Could Help the Fight To Eliminate Malaria

Credit: Pixabay
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Diagnostic Blood Test Could Help the Fight To Eliminate Malaria"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

An international collaborative team from PROS Ehime University and CellFee Science, Japan; the Walter and Eliza Hall Institute, Australia; Pasteur Institute, France; and Foundation for Innovative New Diagnostics, Switzerland developed a new diagnostic blood test which detects recent exposure to ‘vivax’ malaria. The new test can also identify people who may harbor dormant liver-stage malaria parasites, which can cause illness. This new diagnostic approach has the potential to enhance malaria surveillance and accelerate elimination.

Plasmodium vivax is the most widespread malaria parasite worldwide, with up to two billion people at risk of infection. As well as causing illness and death in its 'active' stage of infection, the parasite can hide as hypnozoites, a dormant stage, in the liver, and is a significant cause of 'relapsing' malaria.

These hypnozoites, undetectable with current diagnostics, can be responsible for >80% of all blood-stage infections. Identifying and targeting individuals with hypnozoites is thus essential for accelerating and achieving malaria elimination. A major gap in the P. vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable hypnozoites.

This study developed a panel of serological exposure markers capable of classifying individuals with P. vivax infections within the previous 9 months who have a high likelihood of harboring hypnozoites. 1) We measured IgG antibody responses with the AlphaScreen system to 342 P. vivax proteins expressed by a wheat germ cell-free system, invented at Ehime University, in longitudinal clinical cohorts conducted in Thailand and Brazil and identified 60 candidate serological markers of exposure. 2) Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%.

These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. The test offers new opportunities for improving malaria control and elimination strategies.

Reference: Longley, R. J., White, M. T., Takashima, E., Brewster, J., Morita, M., Harbers, M., . . . Mueller, I. (2020). Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine, 26(5), 741-749. doi:10.1038/s41591-020-0841-4

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement