Early Detection of Lung Cancer
News Aug 11, 2015
The group at Manchester, led by Professor Tony Whetton, Professor of Cancer Cell Biology and Director of the Stoller Biomarker Discovery Centre and the Manchester Precision Medicine Institute, plus Dr Phil Crosbie, Consultant in Respiratory Medicine at the Northwest Lung Centre and senior clinical lecturer at The University of Manchester, will utilise longitudinal pre-diagnosis serum samples from the UKCTOCS biobank to find markers that elevate early, before clinical presentation with symptoms.
Lung cancer is the UK’s leading cancer killer, with nearly 35,000 people dying each year from the disease. Of the 44,500 people diagnosed with lung cancer in the UK each year, only half will still be alive after six months. However, when diagnosed at its earliest stages, up to 73% of non-small cell lung cancer patients will survive for five years or more.
Dr Wendy Alderton, CSO of Abcodia, said: “The University of Manchester is a world leading centre for proteomics and we are excited by the opportunity to work with them on discovering new biomarkers for lung cancer using their SWATH mass spectrometry technology. By combining Abcodia’s expertise in developing tests for the earlier detection of cancer and Manchester’s biomarker discovery skills, we hope to make significant progress in detecting this devastating disease.”
Professor Tony Whetton at The University of Manchester said: “The UKCTOCS sample collection is unique and the opportunity to work with Abcodia further is really exciting to us. We have attracted major funding for biomarker discovery, but you need a great sample collection to make a difference.”
Cancer is one of The University of Manchester’s research beacons - examples of pioneering discoveries, interdisciplinary collaboration and cross-sector partnerships that are tackling some of the biggest questions facing the planet.
Scientists have identified sodium glucose transporter 2 (SGLT2) as a mechanism that lung cancer cells can utilize to obtain glucose, which is key to their survival and promotes tumor growth. The finding provides evidence that SGLT2 may be a novel biomarker that scientists can use to help diagnose precancerous lung lesions and early-stage lung cancers.READ MORE