EKF Diagnostics Collaborates with Joslin Diabetes Center
News Nov 17, 2014
EKF Diagnostics has entered a multi-year, collaborative relationship with Joslin Diabetes Center in support of the ongoing clinical and commercial translation of TNFR1 & 2 biomarkers. These novel biomarkers can help identify patients with Type 1 and Type 2 diabetes that are at an increased risk of developing end stage renal disease (ESRD), up to ten years in advance.
The new agreement between Joslin, an affiliate of Harvard Medical School (Boston, MA, USA), and EKF is part of Joslin’s Corporate Liaison Program (CLP). This program seeks to accelerate development, validation and market introduction of unique products and solutions that advance treatments and care for diabetes and its complications.
As globally recognized leaders in the field of diabetes research, Joslin has created the CLP in order to foster industry partnerships within the pharmaceutical, biotechnology, food and device industries. The role of the CLP is to help engage corporate partners, such as EKF, with Joslin’s capabilities in advisory services, clinical expertise, and research infrastructure. This enables Joslin to work closely with an industry partner to customize its offerings towards a defined product program or a range of corporate priorities within diabetes management.
EKF will access certain clinical and research expertise at Joslin under the CLP to further develop its TNFR biomarker test. The two key objectives of this effort are to:
- Accelerate the clinical development, as well as understanding physician adoption criteria and trends relating to the TNFR-1/2 test.
- Advance the research to support the clinical utility of TNFR 1&2 assays as biomarkers in Diabetic Kidney Disease. This will be accomplished in part by leveraging the collaboration of Joslin with certain partners in the pharmaceutical industry.
“We are excited to collaborate with EKF to advance the development of TNFR1/2 as predictive biomarkers of progressive, diabetic kidney disease,” said Nandan Padukone, VP and Head of Global Business Development at Joslin. “Together we hope to identify patients that are at an increased risk of developing ESRD so that better treatment options can be evaluated.”
Julian Baines CEO of EKF Diagnostics Holdings commented, “We are delighted to announce this exciting collaboration which will help us build upon the significant progress we have made in the last two years. Through our excellent relationship with the Joslin Center we are focused on bringing this test into clinical practice, leading to improved outcomes for diabetic patients at risk of progressive kidney disease”.
This announcement follows an exclusive license agreement between EKF and Joslin in July 2012 to develop and commercialize soluble Tumor Necrosis Factor Receptors 1 and 2 (sTNFR1/2) as predictive biomarkers of progressive Diabetic Kidney Disease.
Study Reveals How MRSA Infection Compromises Lymphatic FunctionNews
Infections of the skin or other soft tissues with the hard-to-treat MRSA bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. Investigators describe how MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes in mouse models, which may contribute to the frequent recurrences of MRSA infection experienced by patients.
Possible Biomarker to Identify Who Would Benefit from ImmunotherapyNews
While immunotherapy has made a big impact on cancer treatment, the fact remains that only about a quarter of patients respond to these treatments. In a new study, researchers examined tissue samples from melanoma and ovarian cancer patients treated with immunotherapies and found a link between the percentage of antigen-presenting cells expressing PD-L1 and an objective clinical response to treatment.READ MORE
Fight Against Cancer: Drug Combination Helps Kickstart the Immune SystemNews
Scientists from King's College London have found a way to boost the immune system to help it fight back against cancer.
The breakthrough involves the first ever use of a combination of chemotherapy and a drug being trialled as a treatment for neonatal jaundice, that together help kick start the body's natural defences.