Horizon Discovery Group to Support Cancer Research UK’s Stratified Medicine Program
News Mar 11, 2015
Horizon Discovery Group plc will be providing genomic Reference Materials to support Phase Two of Cancer Research UK’s Stratified Medicine Programme (SMP). Financial details of the agreement were not disclosed.
The work will focus on supporting the validation of a Cancer Research UK SMP Next Generation Sequencing (NGS) targeted enrichment panel, using Horizon’s HDx human genomic Reference Materials. The NGS project involves multi-gene, multi-aberration tumor analysis and is being run in CPA, GLP and ISO accredited laboratories, with a UK NEQAS (www.ukneqas.org.uk) quality assessment. These Reference Materials will support run-to-run and lab-to-lab longitudinal assessment of performance of the NGS technology.
In Phase Two of the SMP, Cancer Research UK will work with the national Experimental Cancer Medicine Centre (ECMC) network and national genetic testing laboratories to develop a national screening programme for lung cancer samples in the NHS. Once screened, these results will be used to place patients on the National Lung Matrix Trial, run by the Cancer Research UK Clinical Trials Unit (CRCTU) in Birmingham, and led by Prof. Gary Middleton.
The scope of the project involves Horizon’s Diagnostics business unit providing renewable, genetically defined Reference Materials representing a range of genetic aberrations and containing defined allelic mutation frequencies. The Reference Materials developed will enable reliable comparison of assay performance across sequencing platforms, targeted assays and laboratories by providing a common universal reference point.
Many factors contribute to variability in the quality of clinical samples, which is currently a concern within molecular pathology laboratories working towards the clinical application of NGS panels for tumor screening. To address this, Cancer Research UK will use Horizon’s precisely defined formalin compromised Reference Standards to assess the performance of Cancer Research UK’s-SMP NGS, in order to inform any necessary changes in clinical practice surrounding preparation of FFPE samples for downstream NGS analysis.
Dr Paul Morrill, President, Products, Horizon Discovery, said: “Research programs such as Cancer Research UK’s Stratified Medicine Programme form a vital piece of the puzzle in the drive toward personalized, or stratified, medicine as a routine approach for the testing and treatment of cancer. We are delighted to have been chosen to support Cancer Research UK on the delivery of Phase Two of this project.”
Dr Ian Walker, Head of Cancer Research UK’s stratified medicine programme, commented: “Research into stratified medicine is helping us to understand the genetic changes that drive cancer, and to find out how different cancers respond to treatment. Ensuring accuracy in genetic assessment of tumors is a vital part of this process, and we welcome Horizon’s involvement in assisting Cancer Research UK with taking the Stratified Medicine Programme forwards.”
Test For Designer Drugs Could Help Treat Overdose PatientsNews
Medical professionals are scrambling to meet the growing demand for emergency room treatment, but they’re hampered by the lack of a quick and easy test to screen patients for “designer” drugs. Chemists have now developed such a test and are refining it with the hope that hospitals could eventually use it to choose the appropriate treatment.READ MORE
Largest Genetic Study of Osteoarthritis Advances ResearchNews
Osteoarthritis is a complex disease, and the genetic basis of the disease has proved difficult to pin down. A new study from the Sanger Institute provides much-needed hope.READ MORE
Comments | 0 ADD COMMENT
11th International Conference and Exhibition on Metabolomics & Systems Biology
May 17 - May 19, 2018
6th Annual Congress on Biology and Medicine of Molecules
Sep 17 - Sep 18, 2018
World Congress on Pathology and Laboratory Medicine
Sep 10 - Sep 11, 2018