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Scientists Take a Giant Step Closer to Treating Obesity With a Pill

News   Apr 19, 2018 | Original Story from SIMMCAS

Neuropeptide Y Y1 Receptor Structure Solved, Offers New Opportunities for Anti-obesity Drug Discovery

Figure: The crystal structure of Y1R binding to an antagonist UR-MK299. The receptor is shown in blue cartoon and surface representations. The antagonist UR-MK299 is shown as grey spheres. Credit: Dr. WU Beili’s group from SIMMCAS



Neurons Integrate Better with Muscle Grown on Grooved Platforms


“With this approach, we can engineer muscle outside of the body so it can respond like muscle in the body.”


Study Implicates Gum Disease Bacteria in Alzheimer's Pathology


Porphyromonas gingivalis, the central bacterium involved in chronic periodontitis, was found in the brains of Alzheimer’s disease patients. In mice, infection by the bacterium resulted in increased production of amyloid plaque components, and toxic bacterial proteases were observed in the brains of these mice. Small molecules aimed at blocking these proteases rescued some of these pathological features.


High Blood Pressure Linked in Brain Shrinkage Even in Young Adults


For people in their 20s and 30s, having blood pressure above normal but below the level considered to be high blood pressure, may be linked to loss of brain volume, according to a new study. People with blood pressure above normal were more likely to have a loss of volume in the gray matter in certain areas of the brain than people with normal blood pressure.



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