New Diagnostic Tool for Detecting Breast Cancer Developed
SFU researchers and their patent-pending DOB-Scan, which can safely and non-invasively diagnose breast cancer (l-r: Mozhgan Jenab, clinical research associate, Farid Golnaraghi, MSE director, Zahra Haeri, graduate student and Majid Shokoufi, post-doctoral researcher, all from the School of Mechatronics Systems Engineering. Credit: Simon Fraser Univesity
SFU researchers have created a patent-pending, optical diagnostic probe capable of more safely and non-invasively detect early stage breast cancer.
Recent testing of their diffuse optical breast-scanning (DOB-Scan) probe during an initial clinical study at Surrey’s Jim Pattison Outpatient Care and Surgery Centre found that it can conclusively confirm cancer, while also providing more detail about “suspicious tissue” than conventional methods.
How it works
The DOB-Scan probe uses near-infrared light to capture cross-sectional images of breast tissue. The captured images represent concentrations of four main components in the breast—oxy-hemoglobin, deoxy- hemoglobin, water and fat, which are markers of healthy and cancerous tissue in the breast.
“The reconstructed images using the probe correlated well with cancer locations obtained by other clinical modalities such as X-ray mammography and MRI,” says Majid Shokoufi, a post-doctoral fellow in the School of Mechatronics Systems Engineering (MSE).
He has spent the past five years refining the technology, and completed his PhD focusing on the research last fall. “We are also able to read deep within the tissue and capture more detailed information about what it contains.”
Improved screening is promising for women of all ages, notes Farid Golnaraghi, MSE director and research lead.
“Since mammography is recommended for women over 50 and requires radiation, our research has led to a cost-effective, non-invasive method that can complement other screening methods and successfully diagnose breast cancer in its early stages,” says Golnaraghi.
He began the research eight years ago initially focussing on oral and skin cancer. After consulting with the BC Cancer Agency, however, he turned to the critical area of breast cancer diagnosis.
His team includes Majid Shokoufi, graduate student Zahra Haeri, who carried out the study’s data analysis, and Mozhgan Jenab, a clinical research associate at SFU and the Jim Pattison Outpatient Care and Surgery Centre, where she worked with Dr. Rhonda Janzen to carry out the clinical study.
Golnaraghi is hopeful the probe can eventually play a significant role in breast tumor detection and monitoring. Next steps include broadening the study base to include women who have not undergone cancer diagnosis. With a patent filed, the team has plans to commercialize the probe.
Why it matters:
• Breast cancer affects almost one in eight North American women during their lifetime and it is the second leading cause of cancer-related death in women.
• While popular methods in breast cancer imaging include X-ray mammography, ultrasound and magnetic resonance imaging (MRI), the DOB-Scan probe can safely provide more detailed, instant results.
This article has been republished from materials provided by Simon Fraser University. Note: material may have been edited for length and content. For further information, please contact the cited source.
SMi’s 5th Annual Molecular Diagnostics Conference 2018 Agenda ReleasedNews
SMi proudly presents its 5th annual conference on Molecular Diagnostics, taking place at the Holiday Inn Kensington Forum, London, UK on 9th and 10th July 2018, with a half-day post-conference workshops on 11th July 2018.READ MORE
Pap Test Fluids Used to Test for Endometrial & Ovarian CancersNews
Cervical fluid samples gathered during routine Papanicolaou (Pap) tests are the basis of a new screening test for endometrial and ovarian cancers developed by researchers at the Johns Hopkins Kimmel Cancer Center.
Mini Machines Could Help Search for Disease or PollutantsNews
Tiny floating robots could be useful in all kinds of ways, for example, to probe the human gut for disease or to search the environment for pollutants. In a step toward such devices, researchers describe a new marriage of materials, combining ultrathin 2-D electronics with miniature particles to create microscopic machines.READ MORE