Pathology of Septic Shock
Interleukin 15 (IL-15), a cytokine cell signaling molecule, is essential for the maintenance and function of natural killer (NK) cells and CD8-positive (CD8+) T cells. Edward Sherwood, M.D., Ph.D., and colleagues previously showed that NK cells and CD8+ T cells facilitate the pathobiology of septic shock, a life-threatening condition involving organ injury caused by infection.
Now, in studies led by postdoctoral fellow Yin Guo, Ph.D., the researchers demonstrate that IL-15 promotes sepsis by maintaining NK cell numbers and integrity.
They showed that mice missing the gene for IL-15 had improved survival, reduced hypothermia and less proinflammatory cytokine production during experimentally induced septic shock. Administering IL-15 superagonist to the mice regenerated NK and CD8+ T cells and re-established the mortality of septic shock.
Guo, Y., Luan, L., Patil, N. K., Wang, J., Bohannon, J. K., Rabacal, W., . . . Sherwood, E. R. (2016). IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function. The Journal of Immunology, 198(3), 1320-1333. doi:10.4049/jimmunol.1601486
This article has been republished from materials provided by Vanderbilt University. Note: material may have been edited for length and content. For further information, please contact the cited source.
Shire, Microsoft and EURORDIS Form Global Commission to Accelerate Rare Disease DiagnosisNews
The alliance aims to shorten the often multi-year journey that patients and families endure before being diagnosed with a rare disease.READ MORE
Breast Cancer: How Advanced Imaging Technologies Will Help Avoid Unnecessary BiopsiesNews
Scientists have combined an advanced method of diffusion-weighted MR imaging with intelligent image analysis methods to detect malignant changes in tissues. This method may help avoid many control biopsies following suspicious findings from mammography screening.READ MORE
Researchers Discover Key Link Between Mitochondria and Cocaine AddictionNews
Researchers were able to block response in mitochondria to cocaine.READ MORE