Pathology of Septic Shock
Interleukin 15 (IL-15), a cytokine cell signaling molecule, is essential for the maintenance and function of natural killer (NK) cells and CD8-positive (CD8+) T cells. Edward Sherwood, M.D., Ph.D., and colleagues previously showed that NK cells and CD8+ T cells facilitate the pathobiology of septic shock, a life-threatening condition involving organ injury caused by infection.
Now, in studies led by postdoctoral fellow Yin Guo, Ph.D., the researchers demonstrate that IL-15 promotes sepsis by maintaining NK cell numbers and integrity.
They showed that mice missing the gene for IL-15 had improved survival, reduced hypothermia and less proinflammatory cytokine production during experimentally induced septic shock. Administering IL-15 superagonist to the mice regenerated NK and CD8+ T cells and re-established the mortality of septic shock.
Guo, Y., Luan, L., Patil, N. K., Wang, J., Bohannon, J. K., Rabacal, W., . . . Sherwood, E. R. (2016). IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function. The Journal of Immunology, 198(3), 1320-1333. doi:10.4049/jimmunol.1601486
This article has been republished from materials provided by Vanderbilt University. Note: material may have been edited for length and content. For further information, please contact the cited source.
Blood Sample Detection Method for Multiple Sclerosis DiscoveredNews
A method for quickly detecting signs of multiple sclerosis has been developed by a University of Huddersfield research team. The process will avoid the invasive, painful process of collecting fluid from the brain and spineREAD MORE
Infrared Spectroscopy Test Can Diagnose Two Cancer TypesNews
Researchers used mid-infrared spectroscopy to analyze blood serum derived from experimental mice and differentiate mice with non-Hodgkin’s lymphoma and subcutaneous melanoma from healthy mice and also between these two tumorous conditions.READ MORE
Faster, More Accurate Cancer Detection Using NanoparticlesNews
Using light-emitting nanoparticles, Rutgers University-New Brunswick scientists have invented a highly effective method to detect tiny tumors and track their spread, potentially leading to earlier cancer detection and more precise treatment.READ MORE