We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Pathology of Septic Shock

Pathology of Septic Shock content piece image

Want a FREE PDF version of this news story?

Complete the form below and we will email you a PDF version of "Pathology of Septic Shock"

Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.
Read time:

Interleukin 15 (IL-15), a cytokine cell signaling molecule, is essential for the maintenance and function of natural killer (NK) cells and CD8-positive (CD8+) T cells. Edward Sherwood, M.D., Ph.D., and colleagues previously showed that NK cells and CD8+ T cells facilitate the pathobiology of septic shock, a life-threatening condition involving organ injury caused by infection.

Now, in studies led by postdoctoral fellow Yin Guo, Ph.D., the researchers demonstrate that IL-15 promotes sepsis by maintaining NK cell numbers and integrity.

They showed that mice missing the gene for IL-15 had improved survival, reduced hypothermia and less proinflammatory cytokine production during experimentally induced septic shock. Administering IL-15 superagonist to the mice regenerated NK and CD8+ T cells and re-established the mortality of septic shock.


Guo, Y., Luan, L., Patil, N. K., Wang, J., Bohannon, J. K., Rabacal, W., . . . Sherwood, E. R. (2016). IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function. The Journal of Immunology, 198(3), 1320-1333. doi:10.4049/jimmunol.1601486

This article has been republished from materials provided by Vanderbilt University. Note: material may have been edited for length and content. For further information, please contact the cited source.