Sniffing Out Cancer
News Oct 01, 2015
One team has now reported new progress toward this goal. The researchers have developed a small array of flexible sensors, which accurately detect compounds in breath samples that are specific to ovarian cancer.
Diagnosing cancer today usually involves various imaging techniques, examining tissue samples under a microscope, or testing cells for proteins or genetic material. In search of safer and less invasive ways to tell if someone has cancer, scientists have recently started analyzing breath and defining specific profiles of compounds in breath samples. But translating these exhaled disease fingerprints into a meaningful diagnosis has required a large number of sensors, which makes them impractical for clinical use. Hossam Haick and colleagues sought to address this problem.
The researchers developed a small, breath-diagnostic array based on flexible gold-nanoparticle sensors for use in an “electronic nose.” The system — tested on breath samples from 43 volunteers, 17 of whom had ovarian cancer — showed an accuracy rate of 82 percent. The researchers say developing this method further would require larger-scale clinical testing. They add that the approach could also apply to diagnostics for other diseases.
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes.READ MORE