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Achieve Baseline Separation of AAV Full and Empty Capsids for Multiple Serotypes

AAV Capsids
Credit: Cytiva

As demand for adeno-associated virus (AAV) vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empty capsids.

To meet these needs, we developed scalable capture and polishing chromatography steps for recombinant AAV. Here we highlight the polishing step.

Download our poster to learn about:

  • Conditions to achieve baseline separation of AAV full and empty capsids using anion exchange chromatography
  • High VG recovery and full capsid %
  • Reduction of partial capsids for AAV5 and AAV9
  • One single elution buffer for AAV2, AAV5, AAV8, and AAV9 (likely also other serotypes)

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