Expression of stress response protein GRP78 is associated with the development of castration-resistant prostate cancer
Poster Nov 22, 2007
This study investigated the role of the GRP78 in prostate cancer progression and the development of castration-resistant prostate cancer, where cancer cells continue to survive despite the stress of an androgen-starved environment. These findings show that GRP78 upregulation is associated with castration-resistant prostate cancer development, possibly in part by augmenting cell survival, and may serve as an important prognostic indicator of recurrence in a subset of patients with T3N0M0 disease.
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE
We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumors. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.READ MORE