Mass Spectrometry: From Imaging to Metabolic Networks
Poster May 29, 2018
Paolo Inglese, Nicole Strittmatter, Luisa Doria, Anna Mroz, Abigail V M Speller, Liam R Poynter, Andreas Dannhorn, Hiromi Kudo, Reza Mirnezami, Robert D Goldin, Jeremy K Nicholson, Zoltan Takats, Robert C Glen.
A deeper understanding of inter-tumor and intra-tumor heterogeneity is a critical factor for the advancement of next generation strategies against cancer. Under the hypothesis that heterogeneous progression of tumors is mirrored by their metabolic heterogeneity, detection of biochemical mechanisms responsible of the local metabolism becomes crucial.
We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumor. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.
Automation of Sample Preparation for Metabolomic Analysis Using Robotic PlatformPoster
We developed an automated sample preparation protocol based on a robotic platform PAL RTC (CTC Analytics AG, Zwingen Switzerland), which represent a modified Bligh and Dyer method producing samples for both hydrophilic metabolomics using GC-MS and lipidomics using SFC-MS simultaneously.READ MORE
Identifying Non-Intentionally Added Substances (NIAS) in Food Contact MaterialsPoster
Concern about the safety of food products has increased dramatically with intentionally and non-intentionally added substances (NIAS) used in packaging being of particular interest. APGC and high resolution MS together with a workflow driven process was used to identify unknown compounds in packaging.READ MORE
Human exposure to cyanotoxins: Exploring in vitro detoxification using atmospheric cold plasma treatment to protect human healthPoster
Recently, there have been increases in freshwater harmful algal blooms. There is therefore a need to try and effectively detoxify drinking water contaminated with cyanotoxins to safeguard human health by use of new and novel techniques.READ MORE