MicroRNAs as Bile-Based Biomarkers in Pancreatic Cancer and Biliary Tract Cancers
Poster May 09, 2017
M. Mato Prado*1, A. E. Frampton*1,2, N. Funel3,4, E. Lopez-Jimenez1, L. Castellano1, P. Lawton1, L. L. Meijer5, G. Kazemier5, L. R. Jiao2, J. Stebbing*1, E. Giovannetti*4,6, J. Krell*1
Pancreatic cancer is one of the most lethal diseases in the world with 9,618 new cases and around 8,800 deaths in the UK. It is the fourth most common cause of cancer death in the UK (2014). The lack of efficient diagnostic techniques and limited treatment options leads to a late detection and poor survival rates (less than 1%)1.Therefore, further investigation is needed to improve the detection process and design specific molecular targeted treatments.
During last decade, a class of non-coding RNAs (microRNAs) are emerging as potential biomarkers and therapeutic targets for different cancers. In this study, the role of miRNAs has been assessed in a large cohort of pancreatic cancer.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE