Rare Diagnosis of Malignant Mesothelioma in a Young Patient with Rheumatoid Arthritis
Poster Feb 14, 2017
Zein Kattih, Saleh Hasan, Jacques P. Fontaine, MD, Farah Khalil, MD
Malignant pleural mesothelioma is an aggressive malignant neoplasm of the pleural layer associated with asbestos exposure that has a poor prognosis. Studies of malignant pleural mesothelioma in younger cohorts show decreased association with asbestos exposure, longer survival, and overall improved prognosis. Immunohistochemical markers, including calretinin, WT-1, CK5/6, and most recently BAP-1, aid in the pathological diagnosis of the disease. Presented here is the rare case of a young woman with rheumatoid arthritis who is found to have malignant pleural mesothelioma based on pathologic findings.
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE
RNA interference (RNAi) using small interfering RNAs (siRNAs) is an important technology for down-regulation of gene expression and a powerful tool to study cellular processes and pathways. Previously, large collections of siRNAs were available only for traditional experimental model systems, such as human and mouse, and predominantly provided as chemically synthesized libraries.READ MORE