Rare Diagnosis of Malignant Mesothelioma in a Young Patient with Rheumatoid Arthritis
Poster Feb 14, 2017
Zein Kattih, Saleh Hasan, Jacques P. Fontaine, MD, Farah Khalil, MD
Malignant pleural mesothelioma is an aggressive malignant neoplasm of the pleural layer associated with asbestos exposure that has a poor prognosis. Studies of malignant pleural mesothelioma in younger cohorts show decreased association with asbestos exposure, longer survival, and overall improved prognosis. Immunohistochemical markers, including calretinin, WT-1, CK5/6, and most recently BAP-1, aid in the pathological diagnosis of the disease. Presented here is the rare case of a young woman with rheumatoid arthritis who is found to have malignant pleural mesothelioma based on pathologic findings.
When there is a need to quickly analyze samples using a number of different PCR assays, it is likely that optimal conditions for each assay will not be the same. First, different assays often will require different annealing temperatures for their primers. In addition, amplicons may be designed to be of different lengths and therefore require varying durations of the extension step.READ MORE