eXmoor and Virica Receive Funding To Improve AAV Gene Therapy Manufacturing
Complete the form below to unlock access to ALL audio articles.
eXmoor pharma, and Virica Biotech Inc. (“Virica”), announced a new project funded in part through a joint Canada-UK government biomanufacturing collaboration, aimed at improving the manufacture of adeno-associated vector (AAVs), a crucial component of gene therapies. The collaborative project will utilize Virica’s VSEs™, small molecules that have been shown to increase productivity of AAVs, leveraging eXmoor’s scale-up process development expertise to identify top candidates and deploy them at commercial scale upon completion of the project next year.
Commercial gene therapies have remarkable efficacy, utilizing just a single dose to treat and even cure intractable diseases. However, unlike most medicines, these must be made through specialized processes with extremely high manufacturing costs. Making these therapies accessible to more patients and for additional diseases will require streamlining the processes, especially the challenge of growing AAVs in specialized HEK293 cells.
Want more breaking news?
Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.
Subscribe for FREEVirica’s VSE™ library was identified through its High Throughput Virology Platform and includes small molecules that augment innate cellular responses within manufacturing cells. This includes tuning the immune defences of HEK293 cells that otherwise slow the replication of viral vectors. Through the partnership, Virica will develop VSE formulations to enhance AAV production, and eXmoor will optimize the manufacture of vectors with VSEs from small- through commercial-scale capacity.
“We thank Innovate UK for supporting this project, which we believe will benefit not only our work but our entire industry – and most importantly, patients,” said Angela Osborne, CEO of eXmoor. “Together, Virica and eXmoor aim to produce validated and commercially relevant VSE™ enhancer formulations our clients can utilize, as well as other global manufacturing players.”
“The advisory services and funding provided by the National Research Council of Canada Industrial Research Assistance Program and our partnership with eXmoor create a great commercial opportunity to increase efficiency and reduce costs of life-saving therapies,” said Jean-Simon Diallo, co-founder and CEO of Virica. “We look forward to building strong business relationships between Canada and the UK in the process.”
Following a successful application to the Canada-UK Biomanufacturing of Biologics and Advanced Therapies collaborative R&D competition, Virica will receive advisory services and funding from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP) to support their participation in the project, while eXmoor pharma will receive support through Innovate UK, part of UK Research and Innovation.