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Research Project 3TR To Use Breath Biopsy, Improve Immune-mediated Disease Management

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Product News

Research Project 3TR To Use Breath Biopsy, Improve Immune-mediated Disease Management

Credit: Owlstone Medical

Owlstone Medical has joined 3TR, a large-scale public-private research initiative that aims to provide new insights into the mechanisms of response and non-response to treatment within and across seven different immune-mediated diseases. The company will receive funds from the project to provide Breath Biopsy Collection Stations and Kits for the collection of breath samples, and analysis services for multiple studies that have been identified at this stage as suitable to include breath sampling, alongside clinical and physiological evaluation and blood analysis.

The project unites renowned, interdisciplinary experts from 69 academic and industrial partner institutions, including multiple top-ten pharma, covering 15 European countries. Under the initiative, 3TR will have access to an unprecedented quantity of clinical data and samples of more than 50,000 patients across 50 ongoing and new clinical trials, ultimately aiming to discover and verify stratification biomarkers to improve patient management.

Autoimmune, inflammatory and allergic diseases are common chronic diseases that significantly affect the wellbeing of millions of people around the globe and pose a substantial burden to healthcare systems. While different treatments are available, response and disease progression in individual patients remain unpredictable, which can hamper the management of their disease.

In a never-before-seen effort to bring together experts from different medical fields, profiling technologies, systems biology and bioinformatics with specialists from innovative SMEs and leading pharmaceutical companies, 3TR – operating under the IMI2 umbrella – sets out to fundamentally increase knowledge of the molecular pathways and mechanisms linked to response and non-response to a range of therapies.

The work falls within and across seven different immune-mediated, allergic and inflammatory diseases - systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease (including ulcerative colitis and Crohn’s disease), asthma and COPD. Despite their heterogeneity, recent studies have shown that on the molecular level certain patterns are shared by patients across these diseases, thus suggesting they may also share pathways of response to treatment and disease progression.

Breath sampling is expected to be deployed initially into multiple academic-led trials for asthma and COPD, however the potential exists for Breath Biopsy to extend into additional studies in other investigational areas as the 3TR initiative proceeds. Owlstone Medical will have full access to the data generated, and the rights to develop biomarkers discovered into clinical tests.

“For the first time, the 3TR team will align and integrate the analysis of autoimmune, allergic, and inflammatory conditions to identify the relationship between longitudinal molecular and microbiome profiles in blood cells and tissues, and disease paths. In a unique approach we will study the seven diseases both in parallel and jointly”, explains Marta Alarcón-Riquelme, scientific coordinator of 3TR. “We believe that this high-resolution multi-omics profiling analysis of individualized response to treatment and disease progression will facilitate stratification and identification of molecular patterns that better predict response or non-response to therapy. This comprehensive approach will help identify biomarkers to improve patient management within these diseases.”

Billy Boyle, co-founder and CEO at Owlstone Medical, said: “Currently, too little is known about the molecular basis underpinning autoimmune, inflammatory, and allergic diseases. A deeper understanding of the cellular mechanisms driving disease development is urgently needed, which will support the discovery of novel biomarkers, on breath or other sample types that can be deployed to detect disease earlier and to drive improved patient outcomes. 3TR’s ground-breaking approach to addressing this problem through integrated cross-disease analysis, led by leading academic, pharmaceutical, and other organizations, is one that Owlstone Medical is excited to be making a unique contribution to.”

All data generated within the project will be gathered on a centralized data management platform. The latter will enable detailed and comprehensive, state-of-the-art bioinformatics and biostatistics analyses based on machine learning and dynamic, mechanistic methods. By involving medical associations in close relationship with patient groups, 3TR will also contribute to swiftly translating relevant knowledge and project outcomes into clinics.

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