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ANGPT2/TIE2: Attractive Targets for Improved Anti-angiogenic Cancer Therapy
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Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting. Inhibition of ANGPT2 shows promising results in preventing tumor angiogenesis, tumor growth, and metastasis in preclinical models, making it an attractive candidate to target in cancer.
ANGPT2 is highly upregulated at the early stages of tumor progression to drive neovessel formation. Conventional anti-VEGF therapies primarily target immature blood vessels in tumors. The combinational targeting of both ANGPT2 and VEGF pathways is now expected to improve clinical efficacy by expanding the target vessel population. Sino Biologicalhas developed high-quality reagents to support the study of the ANGPT2/TIE2 signaling.
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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