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Common Gamma-Chain Cytokines & Receptors

Common Gamma-Chain Cytokines & Receptors


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The common gamma-chain cytokines signal through cytokine receptors that consist of the common cytokine receptor γ chain (γc/CD132/IL2RG). This family includes at least six short-chain cytokines: IL2, IL4, IL7, IL9, IL15, and IL21.

Besides IL2RG, the γc family cytokine receptors include IL2RB (CD122), IL4R (CD124), IL7R (CD127), IL9R (CD129), and IL21R. The γc subunit binds with these different cytokine-specific receptor subunits to form unique heterodimeric receptors for IL4, IL7, IL9, and IL21, or heterotrimeric receptors for IL2 or IL15, respectively. Currently, designer cytokines targeting this family have shown significant therapeutic potential in allergy, immunodeficiency, autoimmunity, and cancer.

Sino Biological has developed a panel of high-quality recombinant γc family cytokines and receptor proteins and antibodies to support the study of this cytokine family.