HCPs: Byproducts from Biotherapeutics Production
Featured Product ADVERTISEMENT Apr 01, 2021
Host cell proteins (HCPs) are impurities introduced during the production of cell-based biotherapeutics, including recombinant proteins and antibodies. An excessive amount of residual HCPs may severely compromise the safety and efficacy of the product in different ways. Most notably, HCP is known to elicit an unwanted immune response against the drug. There is a critical demand in assays and reagents for the detection and quantification of HCPs.
Chinese Hamster Ovarian (CHO) cell is the most commonly used host organism for the production of recombinant bio-therapeutic products. CHO cells naturally express many types of HCPs, the majority of which can be easily cleaned up during the purification process. But there are a handful of HCPs, most notably the lipases, that can be hard to eliminate.
Sino Biological has developed high purity recombinant lipases, including Chinese hamster PLBD2, PLA2, and LPL (coming soon) proteins. Most of these proteins are produced in CHO cells for authentic assembly and PTM, and can be used as reference materials for HCP assays.
High Purity Recombinant HCPs:
PLBD2 (Cat#: 5A7664-A08C)
PLA2G15 (Cat#: 5A7663-A08C)
Sino Biological is the global leader in recombinant technology, besides various recombinant protein products, we also provide high-quality one-stop protein expression and antibody production services.