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IL-18: A Link between Innate and Adaptive Immunities

IL-18: A Link between Innate and Adaptive Immunities


IL-18 is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in both innate and acquired immunity. IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. IL18 also amplifies the innate immune response by other cytokines, such as GM-CSF, TNF-α, and IL-1β.


IL-18 activates downstream signal transduction in a similar fashion as IL-1β. IL18 binds with its receptor IL-18 receptor α. Following that, an accessory protein, IL-18Rβ, is recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP.


Recent studies have implicated IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to facilitate the study of the biology of IL-18.


Recombinant IL-18 Proteins

Recombinant IL-18 Receptors

Recombinant IL-18 Antagonist

IL-18 Detection Elisa Antibody Pair


About Sino Biological
Sino Biological, an international reagent supplier and service provider, specializes in recombinant protein production and antibody development. All of the products are independently developed and produced, including recombinant proteins, antibodies and cDNA. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements and offers pre-clinical production technology services for monoclonal antibody drug candidates.
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