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IL-18: A Link between Innate and Adaptive Immunities
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IL-18 is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in both innate and acquired immunity. IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. IL18 also amplifies the innate immune response by other cytokines, such as GM-CSF, TNF-α, and IL-1β.
IL-18 activates downstream signal transduction in a similar fashion as IL-1β. IL18 binds with its receptor IL-18 receptor α. Following that, an accessory protein, IL-18Rβ, is recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP.
Recent studies have implicated IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to facilitate the study of the biology of IL-18.
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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