Anticancer Therapies – Multimedia

Poster
Rapid Detection of Somatic Mutations in Cancer Genes
Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.

Poster
Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.

Poster
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.

Poster
Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
3D Tumorspheroid models for improved predictivity in cancer drug discovery.

Poster
Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering
Drug Antibody Ratio (DAR) is a critical factor to the effective design of antibody-drug conjugates (ADC). This poster presents a method for DAR determination based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.

Video
Monitoring Dynamic Interactions of Tumor Cells with Tissue and Immune Cells in a Lab-on-a-Chip
Peter Ertl discusses how for the first time, direct cell-to-cell interactions of tumor cells with bead-activated primary T cells were continuously assessed using an effector cell to target cell ratio of 10:1.

Poster
Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.

Poster
Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.

Poster
Sub-classification of Colorectal Cancer Using Surface Antigen Antibody Microarray and Fluorescence Multiplexing
Colorectal cancer (CRC) is the second most frequent cause of cancer deaths in Australia. Even after resection up to 50% of patients relapse. In an attempt to prevent recurrences chemotherapy is administered to high risk patients. However, as few as 10-20% patients genuinely benefit because the clinical course for individuals with CRC remains difficult to predict, largely due to prognostically heterogeneous groups within same-stage tumour categories.

Poster
Inhibition of DNA methylation does not overcome docetaxel resistance in human breast cancer cells
DNA mehtylation can lead to chemotherapy resistance in cancer. The aim of this study was to investigate the role of DNA methylation in docetaxel-resistant human breast cancer cells. Whereas the DNA methylation machinery is altered in docetaxel-resistant human breast cancer cells compared to docetaxel-sensitive human breast cancer cells, resistance to docetaxel could not be reversed using the DNA methylation inhibitor decitabine.
Advertisement