Next-Generation Sequencing – News and Features

Results of a phase 1 clinical trial for patients with melanoma show that an updated formula and delivery of the NeoVax personalized cancer vaccine is safe, feasible and improves the vaccine-specific immune response generated.

ETH Zurich researchers have generated over 400 human nerve cell types from stem cells using systematic combinations of morphogens and gene activation. This improves disease modeling for conditions like Alzheimer’s and schizophrenia.

Analysis from the Thrombotic Thrombocytopenia Syndrome Consortium has provided critical insights into the rare but serious condition known as vaccine-induced immune thrombotic thrombocytopenia, which has been linked to certain COVID-19 vaccines.

UC Berkeley and Caltech researchers identified a gene circuit in zebrafish that allows heart regeneration after injury. Using CRISPR, they pinpointed key genes like egr1 that may reactivate heart repair in humans.

Salk Institute scientists identified a brain circuit that gives pain its emotional intensity. This CGRP-linked spinothalamic pathway connects to the amygdala, triggering distress and avoidance.

New research suggests that autism spectrum disorder (ASD) has four distinct subtypes: social and behavioral challenges, mixed ASD with developmental delay, moderate challenges and broadly affected.

Researchers at the University of Tartu found that genetic differences in the CYP2C19 gene significantly affect how people tolerate antidepressants. Slow metabolizers faced 49% higher side effect risk, while ultra-rapid ones had reduced risk.

While many patients experience long-term benefits from cancer treatment, some will derive no benefit whatsoever. The study examined RNA sequencing data and clinical outcomes from several prostate cancer clinical trial datasets.

This article explores the latest advancements in food testing and highlights how they are enabling faster, more reliable testing to ensure the safety of the global food supply chain.

This article explores the relationship between the immune system and cancer and outlines therapeutic strategies that leverage a patient’s immune system to treat cancer.