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Pharmacovigilance – Multimedia

Multicolored gummy bears with one giant gummy in the middle.
Video

Some Sugar Free Gummy Bears Are Laxatives. No, Really

Sugar free gummies are delicious, low on calories, and… technically laxatives? Reactions producer Andrew dives into the science to figure out how he can make delicious sugar free gummies without the uncomfortable side effects.
<i>In Vitro</i> Approaches To Risk Assess Chemical-Mediated Changes in Thyroid Function content piece image
Poster

In Vitro Approaches To Risk Assess Chemical-Mediated Changes in Thyroid Function

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.
Comprehensive Characterization of O-Linked Glycosylation in Etanercept by Electron Activated Dissociation content piece image
App Note / Case Study

Comprehensive Characterization of O-Linked Glycosylation in Etanercept by Electron Activated Dissociation

Glycosylation is a common post-translational modification (PTM) that plays a critical role in antibody effector functions. Comprehensive characterization of N- and O-linked glycosylation in protein therapeutics is essential for ensuring drug safety and efficacy.
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Video

Key Factors To Accelerate Drug Discovery

Speaking at Drug Discovery & Development online symposium 2021, Pei Liu from GenScript, presented her talk on monoclonal antibodies.
Five Ways To Measure Immunotherapy Potency content piece image
Listicle

Five Ways To Measure Immunotherapy Potency

This listicle highlights five commonly used cell viability assays and their benefits and limitations in immunotherapy potency testing.
Assessing Mitochondrial Toxicity in Early Drug Development  content piece image
How To Guide

Assessing Mitochondrial Toxicity in Early Drug Development

Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.
Gene Therapy To Treat Epilepsy With Dr. Eric Wengert content piece image
Video

Gene Therapy To Treat Epilepsy With Dr. Eric Wengert

In this Teach Me in 10 episode, Lucy Lawrence is joined by Dr. Eric Wengert, postdoctoral fellow at The Children’s Hospital of Philadelphia to discuss gene therapies used to treat epilepsy.
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eBook

Evaluating Immune Cell Therapy Potency

Download this eBook to learn more about the tools available for evaluating immune cell therapy potency.
Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions content piece image
Video

Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions

Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.
Mitochondrial Toxicity in Drug Discovery content piece image
Infographic

Mitochondrial Toxicity in Drug Discovery

Download this infographic to learn more about mitochondrial toxicity and the novel solutions available for its identification in drug discovery.
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