Pharmacovigilance – News and Features

News
Vitamin E Succinate Helps Control Tumor Growth and Enhance Immunotherapy
Researchers at the University of Chicago Medicine identified vitamin E succinate (VES) as an effective agent in suppressing tumor growth by promoting FTO degradation. This enhances T-cell cytotoxicity and improves response to immunotherapy.

News
Cancer Cells Trick the Immune System by Altering Mitochondria
Researchers have identified the transfer of mitochondria with mutated DNA from cancer cells to immune cells as a key mechanism of immune evasion and resistance to immunotherapy.

News
Stem Cell Shots Unveil a Safer Way To Treat Inflammatory Eye Diseases
Study finds mesenchymal stem cells injected into periocular tissue effectively reduce inflammation in the eyes without harmful side effects.

Article
Addressing Widening Health Disparities With Inclusive Stem Cell Models
Racial disparities in mortality are increasing. This article explores how the production of DNA-edited ethnically diverse stem cell lines for disease research could improve global health equity.

Article
Nanoparticle-Delivered Pain Medication Could Help Address the Opioid Crisis
Professor Dame Ijeoma Uchegbu discusses the nanoparticle delivery system behind the non-addictive pain medication Envelta and how this treatment could help overcome issues surrounding efficacy and off-target effects.

News
Machine Learning Predicts Protein Behavior, Aiding Drug Design
Researchers developed ProtGPS, an AI tool that predicts protein localization in cells and how mutations affect disease. The model identifies functional disruptions and designs novel proteins for targeted therapies.

Article
Organoids, Beyond the Hype
The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.

News
“All-Tablet” Treatment Shows Promise for Common Form of Leukemia
An international study of over 800 chronic lymphocytic leukemia (CLL) patients found that an all-tablet therapy of acalabrutinib-venetoclax – with or without obinutuzumab –improved progression-free survival compared to chemotherapy.

News
Researchers Find Better Treatment for Rare Pregnancy-Related Cancer
Scientists have found a way to combat a rare, aggressive form of cancer affecting pregnant women and to better ensure the drug used for the disease reaches tumor cells without damaging healthy tissue.

News
Cancer Vaccine Shows Promise for Advanced Kidney Cancer
A phase 1 trial of a personalized cancer vaccine for stage III/IV clear cell renal cell carcinoma showed promising results. The vaccine trained patients’ immune systems to target cancer cells, preventing recurrence.
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