RNA-Seq – News and Features

Functional genomics can help deconvolute the link between genotype and phenotype in disease, revealing new drug targets and progressing understanding of existing drugs.

SickKids researchers identified the KCNB2 gene as a key driver of medulloblastoma tumor growth. Blocking KCNB2 disrupts potassium channels, causing tumor-propagating cells to swell and lose integrity.

Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The study reveals TREM2's role in clearing damaged cells and promoting recovery.

Researchers revealed mitochondria's role in immune regulation through IL-10 production, controlled by mitochondrial complex III and ROS signaling pathways. Enhancing mitochondrial function could treat inflammatory diseases like lupus.

Pathogen-fighting immune cells go through a surprising transformation and relocation as they fight infections in the gut.

New insights into fibrolamellar hepatocellular carcinoma could lead to new drugs and significantly improved health outcomes.

More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.

A study reveals how Salmonella enterica leverages a small RNA, ManS, to regulate Neu5Ac metabolism and adapt to the host intestine. ManS originates from the 3′ UTR of mRNA via noncanonical RNase III cleavage.

A machine learning algorithm has been developed to deliver more accurate results from single-cell gene expression database analysis.