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Screening Strategies in Drug Discovery – Multimedia

Screening in Drug Discovery With Richard Cuthbert content piece image
Video

Screening in Drug Discovery With Richard Cuthbert

For this week's Teach Me in 10 video, we're joined by Richard Cuthbert, who discusses screening in Drug Discovery.
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Listicle

Five Advances in Fragment-Based Drug Discovery

Read this listicle to discover recent advancements in fragment-based screening including fragment tailoring, affinity mass spectrometry-based fragment screening and computational approaches using fragments.
Organoids for Disease Modeling and <i>In Vitro</i> Drug Screening content piece image
App Note / Case Study

Organoids for Disease Modeling and In Vitro Drug Screening

While the complexity of organoids remains challenging, technological advances are enabling organoids to be developed and monitored in an automated fashion, so that they can be exploited in high-throughput drug screening assays.
Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis content piece image
App Note / Case Study

Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis

Affibodies are synthetic antigen-binding proteins. They offer many advantages over monoclonal antibodies, including smaller sizes, enhanced thermal stability and rapid refolding capability. These advantages make affibodies an attractive platform for the development of therapeutics, diagnostics and bioimaging technology.
How Stem Cells Are Shaping Drug Discovery content piece image
Listicle

How Stem Cells Are Shaping Drug Discovery

Stem cells are increasingly being used in new and innovative ways to improve the drug discovery process – spanning academia, biotech start-ups and large pharmaceutical companies.
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Listicle

Quantitation in LC-MS

With growing concerns over a multitude of food risks, accurate and sensitive analytical tools are needed to ensure food safety. Liquid chromatography-mass spectrometry (LC-MS) has become an indispensable method for food safety testing and quality control, capable of detecting and quantifying even trace amounts of numerous contaminants and harmful species in food.
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Listicle

Advances in Cell Microscopy

Since the earliest microscopy efforts in the 1600s, cell imaging has significantly modernized and become a ubiquitous tool in cell biology laboratories. Here, we cover five key advances in cell microscopy to help you understand how the field is progressing.
Rapid MS/MS Analysis With Acoustic Ejection Mass Spectrometry content piece image
App Note / Case Study

Rapid MS/MS Analysis With Acoustic Ejection Mass Spectrometry

Download this app note to discover a system that provides high-speed and reproducible quantification, has broad compound coverage and is purpose built for incorporation into high-throughput screening workflows.
Five Top Tips for High-Content Screening in 3D content piece image
How To Guide

Five Top Tips for High-Content Screening in 3D

Download this guide to learn how you can generate uniform 3D cell models, get the best quality images, minimize imaging time and volume of data as well as avoid unnecessary data transfer steps.
Isothermal Titration Microcalorimetry: An Essential Tool for Fragment-Based Drug Discovery content piece image
Poster

Isothermal Titration Microcalorimetry: An Essential Tool for Fragment-Based Drug Discovery

Download this poster to discover how ITC requires minimal assay development and sample preparation, allows early determination and elimination of false positives and can be used to identify fragments that will form a high-resolution co-crystal with the target protein.
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