Single-Cell Analysis – News and Features

This article explores how next-generation sequencing has revolutionized microbiome research, enabling comprehensive analysis of microbial communities and their roles in health and disease.

A new method combines microscopy with single-cell RNA analysis to make the technique more accessible and scalable, giving researchers an advantage in the numbers game of single-cell analysis.

Researchers have created 63 genetically engineered mouse stem cell lines to study autism-related mutations, especially copy number variations (CNVs). The library reveals shared protein production issues across different autism mutations.

Scientists have identified the discrete group of co-activated neurons in the brain that work to suppress binge drinking behaviors. This could become a new therapeutic target for alcohol dependency.

A stem cell platform aims to recreate the brain's immune system using lab-grown human microglia cells, to understand how it functions – and fails – in neurodegenerative disease.

New research from the University of Chicago cautions against the widespread use of fecal microbiota transplants due to the long-lasting, unintended health consequences for recipients.

Integrating blood vessels into organoids could allow them to surpass current size limits while making them more useful as biological models.

Researchers have identified three types of nerve cells connected to intestinal villi, suggesting that previously unknown neural networks regulate fluid balance in the gut.

Today, single-cell technologies are not only dissecting genomic, transcriptomic and proteomic profiles but also enabling dynamic measurements of cellular functions. Bruker's new Beacon Discovery Platform could make this a reality for more labs.

The heterogeneity of fibroblasts is key to developing targeted therapies in regenerative medicine and in the treatment of diseases.