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Structural Biology – Multimedia

Why Protein Structure Matters in Drug Development content piece image
Video

Why Protein Structure Matters in Drug Development

Dr. Steven Almo explains in lay terms why protein structure and shape are important in developing drugs to fight disease.
Beautiful 3-D Reconstructions of Brain Cells and All Their Synapses content piece image
Video

Beautiful 3-D Reconstructions of Brain Cells and All Their Synapses

Prof Jeff Lichtman describes his group's work to map the brain from the synapses up.
NanoBRET™ Assays for Monitoring Protein Interactions in Living Cells content piece image
Poster

NanoBRET™ Assays for Monitoring Protein Interactions in Living Cells

Learn how NanoBRET assays can be used to interrogate protein events such as epigenetic interactions, adaptor recruitment to membrane receptors and proteasomal recruitment of proteins targeted for degradation.
App Note / Case Study

Visualizing Subcellular Vesicles to Quantitate Autophagy in Neuronal Cells

The role of autophagy is of particular interest in the study of neuronal cells, where it helps to maintain protein structure and function over long axonal distances.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis content piece image
Poster

Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
App Note / Case Study

Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D content piece image
Poster

Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore, a major contributor to acute pancreatitis. We are developing small molecule inhibitors of CypD as a possible treatment for AP and other conditions where the MPTP plays a role.
App Note / Case Study

Quantifying µ-Scale Mixing Time of Sodium Hydroxide and Phenolphthalein Using Dolomite's Micromixer System

This application note evaluates mixing using a rapid chemical reaction causing a colour change as the indicator of mixing.
Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics content piece image
Poster

Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics

We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.
App Note / Case Study

Application of microcalorimetry in drug discovery at Exelixis

Understanding the molecular details of drug-target protein interactions is a critical component of the drug discovery process in the modern pharmaceutical industry.
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