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Structural Biology – Multimedia

App Note / Case Study

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
App Note / Case Study

Microcalorimetry As A Tool For Structural Biology

Video

Interfering Peptides Targeting Protein-Protein Interactions

Katja Arndt, University of Potsdam, speaking at Discovery Chemistry Congress 2015.
Video

Exploring Protein-protein Interactions Using Scaffolded and Assembled Peptides as Synthetic Binding Site Mimics

Jutta Eichler, University of Erlangen-Nuremberg, speaking at Discovery Chemistry Congress 2015.
Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve Crystallization content piece image
Poster

Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve Crystallization

The second virial coefficient of Human Serum Albumin (HSA) was measured using a SEC-MALS 20 detector connected to a Refractive Index concentration detector and an online differential viscometer. Two different buffer conditions, Phosphate buffer pH 7.4 and Citrate buffer pH 4.1 were used, which revealed interesting and contrasting data
App Note / Case Study

Tag-lite® two-cell assay: a valuable tool for protein drug discovery

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
App Note / Case Study

Protein Purification Workflow Development Using Bio-Rad's NCO' Chromatography System

High purity protein is a common requirement for biochemical and structural studies. A common approach is to recombinantly express an affinity-tagged version of the protein of interest. This is, however, not always a viable option. This application note discusses protein purification workflow development for untagged proteins and introduce a new indicator of method performance, the purity quotient difference.
mosquito®  Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up  content piece image
Poster

mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
mosquito®  Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up  content piece image
Poster

mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up

This poster demonstrates the ability of TTP Labtech’s mosquito® Crystal and mosquito® LCP to address the issues inherent in the automated set-up of protein crystallisation screen trials, without needing constant instrument configuration changes.
App Note / Case Study

Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias

Using this technique, it was found that while buffer components alone without seed can marginally promote crystal growth in some cases, crystal seeding is far more effective in boosting the number of sparsematrix conditions that yield protein crystals.
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