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Structural Biology – News and Features

Three researchers standing in a lab.

Fluorescent “Dark States” Illuminate Ways Forward for Improved Imaging

St. Jude Children’s Research Hospital scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.
John Lesica, president, chromatography and mass spectrometry at Thermo Fisher Scientific.
Industry Insight

Optimizing Analytical Tools To Accelerate Translational Research

John Lesica, president of chromatography and mass spectrometry at Thermo Fisher Scientific, joined Technology Networks for an interview at this year's American Society for Mass Spectrometry event.
Pink and blue, white and red pill capsules on a white background.

Peptidomimetics Creates New Possibilities in Drug Discovery

Researchers have successfully demonstrated how peptides can be modified to make them promising reagents for drug discovery and diseases diagnostics.
Red blood cells and antibodies flow through a blood vessel.

Protein Complexes Work Together To Coordinate Attacks Against Immune System Invaders

Researchers have uncovered a molecular mechanism that helps the immune system coordinate its response to pathogens and regulate inflammation.
Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents the “buzzer” site in red.

Researchers Identify “Short Circuits” in Cellular Pathways

A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.
A graphic showing how data is translated into protein structures.

Mathematical Method Compares 3D Structure of Proteins

The foundations have been laid for a mathematical method that allows the computer-assisted comparison of 3D protein structures.
Cancer cells.

Neglected Lipid May Play Role in Aggressive Cancers

Scientists at Sanford Burnham Prebys and Vanderbilt University uncover a new role for a neglected lipid that may play a role in aggressive cancers.
Protein structure.

Novel Method Reveals Tissue-Specific Protein Interactions

Researchers developed a novel chemical biology approach to label proteins from specific cells with a bifunctional amino acid probe that allows labelled proteins to be isolated and captures protein-protein interaction through photo-crosslinking.
This digitally-colorized, negative-stained transmission electron microscopic (TEM) image depicted a number of Influenza A virions.

Drug-Like Molecule Shows Promise in Preventing Flu Infection

Scripps Research scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection. The drug-like inhibitors block the virus from entering the body’s respiratory cells.
Double helix structure of DNA.

Designing Peptoids That Mimic Nature’s Helices

Nature is filled with extraordinarily precise molecular shapes that fit together like a hand in glove. Proteins, for example, can assemble into a wide variety of well-defined shapes that grant them their function.