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Structural Biology – News and Features

A strand of DNA coils across the image.

Supercoiled DNA Captures Gyrase in a Molecular Lasso

New research has revealed how DNA gyrase resolves DNA entanglements – by getting lassoed by the supercoiled DNA.
Holes in material.

Discovery of Nanoscale Voids Poised To Enhance the Performance of Filtration Materials

Researchers have unveiled nanoscale voids in three dimensions, using high-powered microscopy and mathematical theory. This advancement is poised to improve the performance of many filtration materials.
Orange and white pills spill from a prescription bottle.

Researchers Decode the Mechanism of Action of Hepatitis B and D Virus Inhibitor

The molecular mechanisms behind the action of the hepatitis B and D virus inhibitor bulevirtide have been revealed, potentially paving the way to more targeted treatments.
A cell with small internal compartments visible.

Chromosome Locations in Individual Cells Revealed by Machine Learning

Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell.
Protein structure.

Scientists Create Atomic-Level Models of Enzymes Linked to Lupus and Alzheimer's

Scripps Research scientists create atomic-level structural models of enzymes associated with autoimmune and inflammatory diseases, including lupus and Alzheimer’s.
A vaccine needle entering a vial.

Patient Who Spontaneously Cleared Hepatitis C Could Inspire Vaccine

By studying individuals who spontaneously clear hepatitis C infections, a team of researchers has identified viable vaccine targets for a disease that infects 70 million worldwide with case numbers increasing every year.
The path of the Candidalysis toxin is mapped in yellow.

Function of Candida albicans Toxin’s Unique Protein Arrangement Uncovered

New insights into the unique protein arrangement of the Candida albicans toxin Candidalysin show promise for new treatments.
A sperm cell zipping up an egg cells.

How Does the Body Avoid Multiple Sperm Fertilizing an Egg?

Some cases of infertility are associated with mutations in the genes that are responsible for egg coat formation. The egg coat is an extracellular matrix essential for egg growth, fertilization and protection of the embryo.
Representation of DNA.

Genetic Tuning: The Next Frontier of Genetic Medicine

Discover how genetic tuning differs from gene editing and other modalities of genetic medicine and how the ability to fine-tune genes will transform precision medicine.

Imaging Protein Dynamics in Native Environments

Cryogenic electron tomography (cryo-ET) is a way to observe proteins in their native environment by imaging frozen cells at different angles to obtain 3D structural information.