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Structural Biology – News and Features

An electron micrograph showing three EBV virions in red-orange.

Researchers Identify Epstein-Barr Virus’ Weak Points

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.
T cells.

STAP-1’s Role in Activating Certain Immune Cells Deciphered

A new study has shed light on the importance of the protein STAP-1 in activating certain immune cells. Understanding the role of STAP-1 in these cells could give researchers a better glimpse into immune-related disorders and ways to treat them.
Protein structure.

Molecular “Brake” Could Help Develop Cancer Immunotherapies

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.
A cell dividing.

New Insights on Altered Protein Folding's Effects on Multicellular Evolution

Researchers have discovered a mechanism steering the evolution of multicellular life, putting the spotlight on the regulation of proteins to understand evolution.
A row of pipettes filled with red liquid

High-Throughput Screening: Advances, Applications and Combined Approaches

In this article, we highlight various high-throughput screening strategies being used to interrogate large libraries of compounds and hear from researchers working to further streamline specific approaches to increase speed and improve quality and accuracy.
Cancer cells.

Fusion Proteins “Hijack” Gene Regulation in Cancer Development, Study Finds

A group of abnormal proteins known as fusion proteins aberrantly engage with a collection of proteins that switches genes on and off. Genes that should be activated get repressed and genes that should be repressed get activated, causing cancer.
Model of the sugar shield (green) on the GABAA receptor (grey) in a membrane (red) generated by GlycoSHIELD.

Sugar-Predicting Software May Help Accelerate Drug Development

Sugars cover nearly all proteins present at the surface of the cells in our bodies, forming a shield around the proteins. Thus, these sugars influence how cells interact with their environment including pathogens.
Various pills on a table with a magnifying glass over one, bringing into focus.

Drug Repurposing Strategies, Challenges and Successes

In this article, we explore the evolution of drug repurposing from a serendipitous occurrence to a more formalized endeavor involving advanced computational approaches and bioengineered test beds, considering its advantages, challenges and successes.
A mitochondria cut in half.

Leaky Mitochondria May Be Drivers of Inflammation

Researchers have discovered how “leaky” mitochondria – the powerhouses of our cells – can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis.
A prescription pill bottle spills tablets of different sizes, shapes and colors.

Existing Drugs Show Early Promise for Lowe Syndrome

A new treatment method that combines two existing drugs has shown early promise for treating Lowe syndrome.