The Immune System – News and Features

According to researchers, IL-15 triggers harmful T-cell activation, but the calcineurin–NFAT pathway acts as a brake, suggesting new therapeutic strategies for autoimmune and viral diseases.

A metagenomic study uncovers how gut bacteria influence coronary artery disease, showing a loss of protective species and activation of harmful metabolic pathways.

A study reveals that NUDT5 regulates purine production, the process that builds DNA, without using its enzymatic activity. Instead, NUDT5 acts as a molecular scaffold that halts DNA synthesis when purine levels are high.

Ongoing peanut patch treatment helps toddlers develop lasting tolerance while remaining safe, offering hope for families managing peanut allergies.

Researchers from Helmholtz Munich found that children of mothers with type 1 diabetes have distinct DNA methylation patterns that may protect against islet autoimmunity. The study identified epigenetic changes in key immune-related genes.

Researchers reported encouraging results from an early phase clinical trial that found an experimental intranasal vaccine triggered a broad immune response against multiple strains of H5N1 “bird flu”.

Researchers showed that a protein language model could design functional human antibodies that recognized unique antigen sequences of specific viruses, without requiring part of the antibody sequence as a starting template.

Researchers have taken a major step toward understanding how certain plants can thrive without chemically produced nitrogen. A breakthrough that could eventually reduce the need for artificial fertilizers in crops such as wheat, maize, and rice.

A specific subtype of tumor-associated macrophage is more abundant in endocrine therapy-resistant tumors, and targeting these could improve treatment.

Researchers have identified a unique microglial population that protects the brain by lowering inflammation and slowing amyloid and tau pathology.