Fit-for-Purpose Biomarker Assay Validation - From Research Tool to Diagnostic Test
Jeff Cummings presents a worked example of circulating tumour cell enumeration as a prognostic/predictive biomarker in cancer research.
New Metabolomics Biomarker for Heart Failure
Metabolomics has been successfully applied to identify and validate biomarkers for congestive heart failure. Diagnosis and risk stratification of heart failure (HF) is challenging.
Creating a Clinical Diagnostic Test from Discovery Through Launch with Mass Spectrometry
Targeted mass spectrometry, called MRM or SRM, allows for the rapid quantification of hundreds of proteins in a single assay. This tool is very specific, highly quantitative and requires very little sample (e.g. < 5 uL plasma).
LC-High Resolution-MS in Clinical Labs: A Step Forward for TDM and Metabotyping
Research/routine and quantitative/qualitative analyses using LC-HR-MS will be presented for drug and peptide determinations in patients’ plasma.
Biomarkers to Predict Aggressive Prostate Cancer
Claire Morgan discusses the need to identify a panel of biomarkers that may distinguish indolent cancer from aggressive metastatic disease when used collectively.
Contributions of Mass Spectrometry in the Diagnosis and Management of Hypothalamic–pituitary–adrenal Axis Disorders
Mass spectrometry is increasingly used in clinical laboratories for the measurement of steroid hormones. In fact, clinical biochemistry and endocrine societies emphasize in their documents the enhanced analytical specificity for mass spectrometry measurements of steroids in comparison with conventional immunoassays.
Biomarkers from Discovery to Clinical Diagnostics Applications of Single-Molecule Array (Simoa) Technology
Andreas Jeromin, Atlantic Biomarkers, speaking at Diagnostics & Biomarkers 2015.
History and Development of High Resolution Mass Spectrometry for Infectious Disease Diagnostics
This presentation will trace the continuing development of mass spectral techniques from a research tool to a frontline diagnostic platform for clinical microbiology.
A Novel Vertically-Integrated Platform for the Discovery and Molecular Characterization of Lung Cancer Stem Cells
Raj Batra, University of California Los Angeles, speaking at Diagnostics & Biomarkers 2015.
Diagnosis of Disorders Affecting Steroid Synthesis and Metabolism by Mass Spectrometry
Despite all the progress in the proteomic and genomic research, the quantitation of steroids in biological samples is still needed for the establishment of the biochemical phenotype of disorders affecting steroid biosynthesis.