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Successful Affinity-Based Lead Identification and Optimization for Challenging Targets and Ligands

It’s not by chance that biophysical methods are becoming an integral part of drug discovery workflows. The reason behind these trends in drug development: targets are becoming more diverse and challenging, demand for fragment-based screening projects is increasing, and the need to identify ligands with different mechanisms of action is rising. Turns out biophysical methods can overcome the obstacles faced with challenging targets and ligands during lead identification. If your screening campaigns are running into similar roadblocks, join us for this talk where we’ll present examples of successful biophysical characterization of binding events during affinity-based screenings that include challenging ligands and targets.