The Application of a Resonant Coil Magnetometer for Point of Care Diagnostic Applications

Video   Jun 10, 2015

 



About the Speaker
Richard Luxton first studied clinical chemistry in the National Health Service for thirteen years at the Bristol Royal Infirmary before moving to the Institute of Neurology in London. At the University of the West of England he has focused his research in the area of developing new rapid detection technologies for point of care diagnostics, environmental analysis, food safety and homeland defence applications. Working with colleagues across the University, Richard launched the Institute of Bio-Sensing Technology, which seeks to develop new collaborations between industry and academia through inter-disciplinary research. In 2012 Richard along with Professor Janice Kiely, launched a European funded Business Technology Centre to develop cell monitoring technology.Abstract
This talk will detail the development of a rapid detection technology for point of care applications using magnetic detection of magnetic material. In this system paramagnetic particles are coated with an antibody directed against the target molecule in the sample. A second antibody to the target is immobilised on a sensor surface, sitting above a resonant coil. Sample is mixed with the antibody coated paramagnetic particles and added to a reaction chamber containing the sensor surface. The target antigen is captured on the particle surface and then acts to cross-link the paramagnetic particles to the sensor surface via the immobilised antibody on the sensor surface. The binding to the surface is accelerated through the application of an external magnetic field that attracts the paramagnetic particles to the sensor surface. The resonant coil detects the captured paramagnetic particles on the sensor surface through a change in inductance of the coil which in turn causes a drop in the resonant frequency. This system enables a rapid assay to be developed that give results in 4 to 5 minutes. This talk will discuss the operating principle of the assay and give examples of assays developed.

 
 
 
 

Recommended Videos

An Expert Insight Into the Issue of Microplastics

Video

We spoke to Dr Andrew Mayes Senior Lecturer at the University of East Anglia, about the growing problem of microplastics, their source, impact and what can be done in the future.

WATCH NOW

Contrasting LBAs and LC-MS for Peptide and Protein Bioanalysis

Video

Kelly Doering discusses ligand binding assays (LBAs) and compares the advantages and limitations of this technology to LC-MS.

WATCH NOW

Introducing Intelligent Fingerprinting: Drug Screening at Your Fingertips

Video

Scientists have developed a revolutionary new fingerprint drug test, the first of its kind in the world.

WATCH NOW

 

Comments | 0 ADD COMMENT

Like what you just watched? You can find similar content on the communities below.

Applied Sciences Drug Discovery

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE

We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy