We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Why Are Polygenic Risk Scores Important?

Video   Aug 20, 2018 | Shared with permission from the Broad Institute of MIT and Harvard University

 

Polygenic risk scores are are calculated using data from genome-wide association study (GWAS) summary statistics.

In polygenic risk scoring, the number of risk alleles carried by an individual are summed, and weighted by the effect size from the discovery GWAS. 

Using data from 400,000 participants in the UK's Biobank initiative, polygenic risk scoring can be used to help ID those at risk for five deadly diseases, including coronary artery disease and breast cancer.

Sekar Kathiresan explains the place of capturing polygenic risk scores in healthcare and how it can be integrated with other measures of risk.

Speaker: Dr Sekar Kathiresan, Director of the Center for Genomic Medicine, Massachusetts General Hospital and Director of the Cardiovascular Disease Initiative and Institute Member, Broad Institute.

Video credit: the Broad Institute of MIT and Harvard University.

 
More Information
 
 
 

Recommended Videos

Cell Culture Basics

Video

An overview of aseptic techniques

WATCH NOW

Should You Eat a Low-gluten Diet?

Video

When healthy people eat a low-gluten and fibre-rich diet compared with a high-gluten diet they experience less intestinal discomfort including less bloating, a new study shows. The researchers attribute the impact of diet on healthy adults more to change in composition of dietary fibres than gluten itself.

WATCH NOW

Allergic Reaction Signature Detected in 5 Minutes

Video

abbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Cancer Research Genomics Research Informatics

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE