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Detection and Monitoring of Host Cell Proteins With LC-MS

Host Cell Protein
Credit : iStock

When mammalian, yeast and bacterial expression systems are used for biopharmaceutical development, host cell proteins (HCPs) can contaminate the end product and pose a significant safety risk.

HCP-mass spectrometry (HCP-MS) analysis can be used to achieve greater coverage and information on the biopharmaceutical HCP profile than using an enzyme-linked immunosorbent assay (ELISA) alone.

This whitepaper explores how to track HCPs of concern through purification steps, develop robust removal strategies and increase the HCP population coverage achieved.

Download this whitepaper to learn more about: 

  • Qualitative identification of HCPs
  • Relative abundance quantitation and absolute quantitation
  • Method qualification and validation for GMP release

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