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Identify and Quantify Individual Host Cell Proteins

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ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s.

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Signals Notebook: Finally More Time For Science

Video

PerkinElmer Signals Notebook allows you to achieve meaningful scientific breakthroughs – faster and smarter.

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Researchers love this microplate spectrophotometer - Thermo Scientific Multiskan Sky

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Plate reader with ready-made protocols, cloud connected, touch screen, no learning curve. Researchers from the University of Helsinki Pharmacy dept. review the Thermo Scientific Multiskan Sky Microplate Spectrophotometer as efficient and easy-to-use.

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Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
News

A new approach to analyzing cell membrane proteins in situ could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases.

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Arming Drug Hunters: Chemists design new reaction for drug discovery
Arming Drug Hunters: Chemists design new reaction for drug discovery
News

The pair of Colorado State University organic chemists have forged a powerful new tool for drug hunters - a simple, elegantly designed chemical reaction that could fling open an underexplored wing of biologically relevant chemistry.

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Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
News

A new Tel Aviv University study finds that the drug candidate CP201, also known as NAP, may improve vocal communication abilities that are underdeveloped in Activity-dependent neuroprotective protein (ADNP) patients.

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New Inflammation Inhibitor Discovered
New Inflammation Inhibitor Discovered
News

A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action.

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Leukemia Stem Cells Rely on Amino Acids for Survival
Leukemia Stem Cells Rely on Amino Acids for Survival
News

Clinically relevant eradication of leukemia stem cells could be achieved with drugs that target their metabolic vulnerabilities.

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Scorpion Venom Can Shuttle Drugs into the Brain
Scorpion Venom Can Shuttle Drugs into the Brain
News

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain.

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High-Throughput LC-MS for Early Drug Screening and Biomarker Detection
High-Throughput LC-MS for Early Drug Screening and Biomarker Detection
Article

In this article, we explore two novel high-throughput analytical methods based on liquid chromatography-mass spectrometry (LC-MS) analysis that can augment early drug screening and biomarker detection in the clinic.

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Liver Spheroids:  A Major Step Towards Meaningful In Vitro Testing for Human Hepatotoxicity Potential
Liver Spheroids: A Major Step Towards Meaningful In Vitro Testing for Human Hepatotoxicity Potential
Article

The development of new in vitro models to replace in vivo testing has already proven quite successful for certain targets. Among these are models of the immune system and human skin, while in vitro cardiac arrhythmia models are poised to emerge in the near future. Despite this clear progress, an efficient model for liver organ toxicity testing still remains elusive.

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Medical Devices: How to Master New Clinical Evaluation Report Criteria
Medical Devices: How to Master New Clinical Evaluation Report Criteria
Article

To achieve regulatory compliance and authorization for sale in Europe, every medical device must be supported by a Clinical Evaluation Report which documents the entire clinical evaluation process. Read on for recommendations on how manufacturers can keep up with the changing regulation landscape.

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Artificial Intelligence, Real Solutions: How AI Can Accelerate Drug Discovery
Artificial Intelligence, Real Solutions: How AI Can Accelerate Drug Discovery
Article

The rate at which new drugs are discovered is in decline, and computer-aided drug design has not produced the radical change in the success of candidate drugs the pharma industry anticipated. Artificial intelligence (AI)-based approaches are the new hope for revolutionizing the drug discovery process. But are these, as computer-aided drug design was, an over-hyped time bomb waiting to be found out? Or is it truly a revolution on the cusp of realizing its promise?

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Antigenic Drift vs Antigenic Shift
Antigenic Drift vs Antigenic Shift
Article

As part of the host-pathogen arms race, viruses are continually evolving to evade the host immune response, be it from previous infection or immunity acquired through vaccination. Here we take a look at the processes of antigenic drift and antigenic shift.

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Exploiting Epigenetics in Cancer Treatment
Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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