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Drug Discovery

Drug Discovery

The Latest Regulatory Guidance for Data Integrity and Regulatory Compliance

The Latest Regulatory Guidance for Data Integrity and Regulatory Compliance

Owing to widespread data falsification and poor data management practices, data integrity and compliance with good manufacturing practice (GMP) regulations are currently a major topic in the pharmaceutical industry. To aid our understanding of data integrity concerns, regulatory authorities have issued guidance documents on the topic. This article will give an overview of this guidance and review specific requirements for computerized systems.

Star Staining for CAR-T research

Star Staining for CAR-T research

“Star Staining” is the new-generation site-specific labeling technology platform and a series of exclusive fluorescent-labeled proteins developed and specifically designed for the quality control and clinical trials in the research of cell therapy, controlled by ACROBiosystems’ “Star standard”.

Screening Strategies Used in Drug Discovery

Screening Strategies Used in Drug Discovery

This article highlights some of the different screening strategies used during drug discovery. Key advances and challenges associated with the techniques are also discussed.

Arrayjet – Inkjet Microarray Instruments

Arrayjet – Inkjet Microarray Instruments

Arrayjet provides microarray instruments and services to the pharmaceutical, diagnostic and life science industries. Our unique inkjet platform combines the fastest and most reliable instrumentation on the market with the versatility to print any biological sample type onto any solid substrate.

Arrayjet – Inkjet Microarray Instruments

Arrayjet – Inkjet Microarray Instruments

Arrayjet provides microarray instruments and services to the pharmaceutical, diagnostic and life science industries. Our unique inkjet platform combines the fastest and most reliable instrumentation on the market with the versatility to print any biological sample type onto any solid substrate.

Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism (Webinar)

Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism (Webinar)

Aldehyde oxidase (AO) enzyme has gained increasing attention in drug development as one of the alternative approaches to reduce P450-mediated drug metabolism liability. However, clinical failure due to poor prediction of AO-mediated clearance is a major hurdle in development of drugs that are AO substrates.

News

New Study Probes Mechanisms Behind Viral Variants

New Study Probes Mechanisms Behind Viral Variants

An international consortium has succeeded in clarifying at the molecular level how RNA viruses recombine.

Repurposing Cancer Drugs To Treat Rare Diseases

Researchers have used computational and experimental approaches to identify cancer drugs that have shown promise for treating pulmonary hypertension, a rare and incurable lung disease

New Test Measures Multiple Areas of Platelet Response

People at risk from strokes and heart attacks could benefit from personalized clotting profiles to help clinicians prescribe more precise treatments, thanks to new research.

Protein Focuses Immune Attack on HIV-Infected Cells

Armed with a novel strategy they developed for bolstering the body’s immune response, scientists at Albert Einstein College of Medicine have successfully suppressed HIV infections in mice—offering a path to a functional cure for HIV and other chronic viral infections.

COVID-19 Reinfection Likely Among Unvaccinated Individuals

Using a statistical model, researchers have assessed the durability of natural immunity against COVID-19, and have found that reinfection is likely among unvaccinated individuals.

Articles

The Role of Neuropilin-1 in SARS-CoV-2 Infection

The Role of Neuropilin-1 in SARS-CoV-2 Infection

Dr. Maria Anastasina from the University of Helsinki and colleagues have been investigating the involvement of neuropilin-1 in SARS-CoV-2 cell entry and infectivity. Technology Networks had the pleasure of speaking with Anastasina to learn more about this work.

Gut Instinct Should Not Play a Part in Drug Repurposing

Technology Networks spoke to Ahmad Besaratinia, PhD, professor of Research Population and Public Health Sciences, Keck School of Medicine of USC to find out more about drug repurposing and the dangers that come with using a drug without fully assessing its potential for harm.

Reconnecting at ELRIG Drug Discovery 2021

Technology Networks is delighted to be reporting – in person – from The European Laboratory Research & Innovation Group (ELRIG)'s Drug Discovery 2021 meeting. In this article, we explore the key themes discussed in the meeting's opening address.

Are Cloud Computing Services Combating Challenges of Data Security, Compliance and Flexibility?

In this article, we discuss the challenges and benefits of operating in the cloud, focusing on how this model ensures data security and compliance, creating a flexible and scalable resource for all laboratories.

Uncovering Key Interactions Between Cancer-Driving Proteins

Research conducted as part of the Cancer Cell Map Initiative (CCMI), has revealed interactions between cancer-driving proteins, that were unknown, until now. Findings were published in three separate papers in Science.

Infographics

Transforming Drug Discovery With Single-Cell CRISPR Screens

Transforming Drug Discovery With Single-Cell CRISPR Screens

Optimizing Your Cryopreservation

Optimizing Your Cryopreservation

What Are the Key Psychedelic Drugs?

What Are the Key Psychedelic Drugs?

Videos

How To Communicate Science Effectively With Professor Yotam Ophir

How To Communicate Science Effectively With Professor Yotam Ophir

DonorPlex™ Pooled Donor Human Hepatocytes Enable the Next Level of Reliability | Lonza

DonorPlex™ Pooled Donor Human Hepatocytes Enable the Next Level of Reliability | Lonza

How To Optimize Your Spray Drying Process

How To Optimize Your Spray Drying Process

How To Guides

Organoid Culture Handbook

Organoid Culture Handbook

While methods for generating organoids are still evolving, presently they are providing exciting and more accurate systems that are advancing our understanding of basic organ biology and tissue regeneration.

How To Pipette Accurately

Download this guide to learn how to avoid instrument damage, volume inaccuracies and sample and reagent contamination.

A Clear and Easy Guide to ELISAS

Download your guide to learn the answers to commonly asked questions such as what is at the core of your immunoassay as well as why use an ELISA over other techniques?

De-Risking Cell Culture: Getting Canny With Contamination

Download this guide to learn how to achieve effective aseptic technique, identify microbial infections and develop essential contingency plans.

Best Practices for Returning to the Lab

Download this free how to guide to learn more about the tips and best practices for returning to the lab after an unexpected shutdown.

Webinars

Advances in Drug Discovery and Development

Advances in Drug Discovery and Development

Decoding the Developing Human Immune System

Decoding the Developing Human Immune System

Fighting Toxic Chemicals – Evaluating the Safety of Cobinamide as a Neutralizing Agent

Fighting Toxic Chemicals – Evaluating the Safety of Cobinamide as a Neutralizing Agent

Listicles

Contamination Control During Biopharmaceutical Processing

Contamination Control During Biopharmaceutical Processing

Ketamine, MDMA, DMT and Psilocybin: A Closer Look at Four Psychedelics

Therapeutic Antibody Engineering: Past, Present and Future

Three Advances in Alzheimer’s Disease Diagnostics

Gut Feeling: How the Gut–Brain Axis Affects Our Mood

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