Compound as Effective as FDA-Approved Drugs Against Life-Threatening Infections
NewsPurdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.
Read moreChemists Design 'Mini-ecosystems' to Test Drug Function
NewsScripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.
Read moreTargeting the Engine Room of the Cancer Cell
NewsResearchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them.
Read moreIntegrated Lead Discovery: An Evolving Toolbox
NewsA new SLAS Discovery review article offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
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Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells
ArticleAlthough cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.
Read moreFood Safety Warnings Are Making Eating More Dangerous
ArticleFood hazard warnings are making eating more dangerous
Read moreExploiting the Glycome for Cancer Therapeutics
ArticleThe surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.
Read moreScientists Explore the Molecular Mechanics that Drive us to Sleep
ArticleScientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles
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