Advances in Fragment-Based Drug Discovery

Article

Over the past decade, fragment-based drug discovery has garnered increasing interest among drug discovery experts and has established itself as a key approach within the field – acting as an alternative starting point for the discovery of high-quality lead candidates. This article discusses the evolution of FBDD, highlights key drug discoveries, and explores the advantages and challenges of harnessing this approach

Read more

Now you can visualize and analyze complex 3D cell models – with Harmony 4.8 software

Video

See what you’re missing with the new capabilities of Harmony® 4.8 software for imaging, analysis, and visualization of complex 3D cell models.

Watch Now

PerkinElmer VICTOR Nivo Multimode Plate Reader - So Much Science So Little Bench Space

Video

The VICTOR Nivo system: The next big thing in plate readers is now the smallest.

Watch Now
Compound as Effective as FDA-Approved Drugs Against Life-Threatening Infections

Compound as Effective as FDA-Approved Drugs Against Life-Threatening Infections

News

Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.

Read more
 
Chemists Design 'Mini-ecosystems' to Test Drug Function
News

Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.

Read more

Targeting the Engine Room of the Cancer Cell
News

Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them.

Read more

Integrated Lead Discovery: An Evolving Toolbox
News

A new SLAS Discovery review article offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

Read more

 
 
 
 
Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells

Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells

Article

Although cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.

Read more
 
Food Safety Warnings Are Making Eating More Dangerous
Article

Food hazard warnings are making eating more dangerous

Read more

Exploiting the Glycome for Cancer Therapeutics
Article

The surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.

Read more

Scientists Explore the Molecular Mechanics that Drive us to Sleep
Article

Scientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles

Read more

 
 
 
 

We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy