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Developing a Successful Assay for Active Pharmaceutical Ingredients

List

In this list, we discuss the process of developing an assay – a crucial test during various stages of drug discovery and development – highlighting the factors that impact the process.

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Stunner bangs out protein quant and characterization in one shot

Webinar

Quantification and quality measurements are both integral parts of protein characterization workflows. These parameters have previously been collected separately, simply due to the lack of tools that can measure both.

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Identify and Quantify Individual Host Cell Proteins

Webinar

ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s.

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Proactive Approach Protects Population From HIV

Proactive Approach Protects Population From HIV

News

A preventative approach to HIV drastically reduced the number of HIV diagnoses in New South Wales, Australia.

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Immune Therapy Shows Promise for Ankylosing Spondylitis
News

Patients who have not benefited from standard therapy for ankylosing spondylitis (AS), a chronic inflammatory disease characterized by back pain and sacroiliac-joint damage, may soon have another option.

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Making Custom-designed Natural Products
News

Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists have now discovered how these enzymes interact with each other, bringing them one step closer to their goal of engineering peptide natural products.

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5.1 Million Dollar Funding Boost for Blinding Retinal Conditions
News

A $5.1 million grant has been awarded from the California Institute for Regenerative Medicine to advance the development of a novel therapy for blinding retinal conditions.

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Exploiting Epigenetics in Cancer Treatment
Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Through the Looking Glass of Single Cell Proteomics
Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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Unlocking the Secrets of Brain Organization -in the Fruit Fly
Unlocking the Secrets of Brain Organization -in the Fruit Fly
Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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Microfluidic Diagnostic Tools: Could Doctors Soon Be Obsolete?
Microfluidic Diagnostic Tools: Could Doctors Soon Be Obsolete?
Article

The world of microfluidics has generated a host of intricate tools on a microscale, ranging from cheap paper-based lateral flow tests to organ-on-a-chip models designed to facilitate personalized diagnostic tests.
This article explores the extent to which microfluidic tools are filling a gap in clinical and point-of-care diagnostics, and touches on how microfluidics could improve the drug discovery process.

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Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Article

Mass spectrometry imaging (MSI) is a powerful tool increasingly being used in many fields including cancer research, biomarker discovery and drug development. This article explains why MSI is the technique of choice in many labs, discusses its use in research, and covers how some inherent challenges are being addressed.

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MALDI Imaging Mass Spectrometry (MALDI IMS): A Marriage of Mass Spectrometry and Morphological Spatial Resolution
MALDI Imaging Mass Spectrometry (MALDI IMS): A Marriage of Mass Spectrometry and Morphological Spatial Resolution
Article

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful analytical technique that enjoys the sensitivity of mass spectrometry coupled with spatial distribution information.

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