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Optimizing Starting Material Quality for Cellular Therapeutics

Article

When a company strives to make an excellent product, they start with the highest quality materials. Cell therapy is unique in that the building blocks for the “product” are living human cells; since each donor is unique, variability is inevitable. Choosing optimal apheresis instrumentation and collection methods is one of the most important steps in ensuring high-quality starting material.

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In situ RNA Hybridization for Drug Discovery: 8 Considerations

List

In situ RNA hybridization has been an important method in the researcher’s toolbox for decades, and it is being continually refined to increase its scope. This list highlights 8 points to consider when using in situ RNA hybridization for drug discovery.

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Delivering Assurance and Credibility: Using Modern Software Systems to Ensure Compliance

Infographic

With computerized laboratory systems now taking the place of paper systems, your compliance strategy must adapt, or you risk difficult regulatory inspections.

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Tackling Antibiotic-resistance: Nitric Oxide-based Treatments for Respiratory Diseases

Blog

The failure of conventional antibiotics to treat numerous antibiotic-resistant infections necessitates the development of new agents – as a natural anti-microbial nitric oxide holds particular promise.

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New Class of Drugs May Reduce Cardiovascular Risk by Targeting Gut Microbes

New Class of Drugs May Reduce Cardiovascular Risk by Targeting Gut Microbes

News

Researchers at Cleveland Clinic in the United States have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut.

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Medicine of the Future Against Infection and Inflammation?
News

Researchers have mapped how the body's own peptides act to reduce infection and inflammation by deactivating the toxic substances formed in the process.

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Tdap Vaccination for Pregnant Women Does Not Increase Risk of Autism, Finds Study
News

A Kaiser Permanente study of more than 80,000 children born over a 4-year period showed that the prenatal Tdap vaccination (tetanus, diphtheria, acellular pertussis) was not associated with increased risk of autism spectrum disorder in children.

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Rotavirus Vaccine Cuts Infant Diarrhoea Deaths by a Third in Malawi
News

A major new study has shown that rotavirus vaccination reduced infant diarrhoea deaths by 34% in rural Malawi, a region with high levels of child deaths.

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Cell Culture Quality Control: Blissful Ignorance?

Cell Culture Quality Control: Blissful Ignorance?

Article

How can quality control efforts keep up with the rapid advances in cellular model research? Read on for insights into challenges in recognizing and managing issues in cell culture quality control

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UHPLC- Robust Technology Built to Perform
Article

Chromatography is the backbone of analytical laboratories with high performance liquid chromatography (HPLC) representing the largest portion. Classical HPLC has been challenged - or complemented - in the last decade by ultrahigh performance liquid chromatography (UHPLC).

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Epigenetics and Drug Discovery
Article

This article aims to highlight the key types of epigenetic modification, summarize current and emerging drug discovery efforts to target epigenetic dysregulation and will discuss some of the benefits and challenges of epigenetic therapeutics.

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Current Trends in Bispecifics, Dual-action and Combination Therapies
Article

It’s becoming increasingly apparent that treatments for complex diseases such as cancer, neurodegenerative diseases and depression are unlikely to target a single molecule in the pathological pathway. Drug developers are turning to new ways to exploit more than one drug target at a time.

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