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10 Things We Didn't Know Last Week, September 21, 2018

List

10 news stories from across the world of science guaranteed to make you sound more interesting

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Challenges & Solutions in Today's In Vitro Transporter Research Landscape

Video

Key concepts discussed in this webinar included: - Ramifications of recent FDA in vitro DDI guidance changes to transporter study designs - Challenges from diverse compounds in otherwise straightforward assays - Solutions to problems associated with specific compound characteristics - Case studies of problematic observations or data and the creative methods of troubleshooting applied

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Developing RNA Medicines for Rare Genetic Diseases

Blog

There are approximately 7,000 known rare diseases, however, less than 6% of these have a treatment. It is estimated that between 25–35 million Americans live with a rare disease. The company ProQR is dedicated to developing new therapeutics for patients living with untreated rare diseases. We caught up with Daniel de Boer, Chief Executive Officer at ProQR to learn more about the company’s approach to finding new treatments for rare genetic diseases.

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Party 'Pus: Ecstasy Makes Octopuses More Social
Party 'Pus: Ecstasy Makes Octopuses More Social
News

When people take MDMA, the drug popularly known as ecstasy, a rush of serotonin, dopamine, and oxytocin makes people more interested than they would normally be in connecting and sharing with other people. Now, researchers have made the surprising discovery that a species of octopus considered to be asocial responds to MDMA in the same way.

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Ovarian Cancer Biomarker Can Predict Patient Therapy Response
Ovarian Cancer Biomarker Can Predict Patient Therapy Response
News

Researchers have identified an independent prognostic factor - cancer/testis antigen 45 (CT45) - and have begun to elucidate it's actions. CT45 is associated with extended disease-free survival for women with advanced ovarian cancer.

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Probing Yeast Cells to Understand Cell Misregulation
Probing Yeast Cells to Understand Cell Misregulation
News

Manipulating yeast with optogenetics and microfluidics to explore the MAP kinase pathway may be key for drug discovery.

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Computational Models of the Human Lung: Potential for Personalized Medicine & Inhalation Toxicology
Computational Models of the Human Lung: Potential for Personalized Medicine & Inhalation Toxicology
News

Combining high-performance computing, high-fidelity modeling, and high-resolution medical imaging, produces simulations that have the potential to contribute to new diagnostic tools and treatment options for respiratory disease.

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Observing Cancer Cell Behavior
Observing Cancer Cell Behavior
News

A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics.

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Existing Drug Could Treat Porphyria
Existing Drug Could Treat Porphyria
News

An existing antifungal drug, ciclopirox (CPX), has been shown to improve symptoms associated with congenital erythropoietic porphyria – the rarest type of porphyria.

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Three Ways to Turn Life Science Suppliers into Partners
Three Ways to Turn Life Science Suppliers into Partners
Article

A growing number of life science businesses are turning to greater supply chain collaboration for benefits like accelerated time to market, improved quality, reduced risk and more rapid and widespread innovation. But while 68% of executives in this industry say active and meaningful engagement with suppliers is essential to success, far too many, over a third, struggle to implement it.

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Advanced Data Analytics in Pharma: Going Beyond Patterns to Understand the “Why”
Advanced Data Analytics in Pharma: Going Beyond Patterns to Understand the “Why”
Article

New developments in pharmaceuticals have made new drugs and treatments available, enhancing options and quality of life for patients. Advanced data analytics solutions mean treatments are more effective and affordable, and less intrusive. However, these evolutions will mean major changes in how companies interact with patients and caregivers, and this will necessitate new capabilities for operations and supply chain.

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Antimicrobial Resistance – the Rise of Global Superbugs
Antimicrobial Resistance – the Rise of Global Superbugs
Article

Antimicrobials have revolutionized medicine by enabling treatments for diseases that would once have proven fatal, however,they have since proven to be a double-edged sword.

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Scientist Explains How They Un-picked Pick’s Disease
Scientist Explains How They Un-picked Pick’s Disease
Article

Scientists use Cryo-EM to solve the structure of the frontotemporal dementia-causing tau protein tangles.

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How Can We Make Behavioral Science More Reproducible?
How Can We Make Behavioral Science More Reproducible?
Article

A scientist explains how, by making 'stock' behavioral tasks more accurate, we can improve reproducibility.

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Imaging in Biology: How Many Words are Cell Images Worth?
Imaging in Biology: How Many Words are Cell Images Worth?
Article

They say 'a picture is worth a thousand words.' Is this true for cell images?

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