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Identify and Quantify Individual Host Cell Proteins

Webinar

ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s.

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Discovering Druggable Targets

Article

We recently spoke to Dr Kilian V. M. Huber from the Structural Genomics Consortium & Target Discovery Institute, University of Oxford to find out – ‘What makes a good target?’.

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Top 10 Biopharma News Stories of 2018

List

It has been a big year for the biopharma world. In case you missed them, here is a list of the top 10 most-read biopharma news stories we have published in 2018.

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Signals Notebook: Finally More Time For Science

Video

PerkinElmer Signals Notebook allows you to achieve meaningful scientific breakthroughs – faster and smarter.

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Compound Blocks Common Genetic Cause of ALS & Frontotemporal Dementia

Compound Blocks Common Genetic Cause of ALS & Frontotemporal Dementia

News

Writing in the journal Cell Chemical Biology, Scripps Research chemist Matthew Disney, PhD, and colleagues describe a new compound that blocks the most common genetic cause of both familial ALS and frontotemporal dementia.

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Alzheimer's Trafficking Defect Corrected in Rodents
News

UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer’s disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the disease in 50 to 80 percent of at-risk adults.

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How Anti-psychotic Medications Drive Weight Gain
News

About three million Americans take antipsychotic medications for conditions such as bipolar disorder, PTSD and schizophrenia. These medications are vital for mental health, yet many people stop taking them because of the side effects of weight gain and associated metabolic diseases.

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CRISPR-edited Stem Cells Reveal New Contributors to Diabetes Development
News

Chronic cellular stress mechanisms have been linked to the poor development of insulin-producing cells, in a study using gene-edited stem cells.

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Cell Signaling in Cancer
Cell Signaling in Cancer
Article

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.

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Target Identification & Validation in Drug Discovery
Target Identification & Validation in Drug Discovery
Article

This article highlights the properties of an attractive drug target, outlines the approaches used to identify targets, and discusses the key steps involved in target validation and the benefits and challenges of using siRNA to validate targets.

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Light Sheet Imaging Helps Capture Zebrafish Neural Development
Light Sheet Imaging Helps Capture Zebrafish Neural Development
Article

A video showing the birth of an incredible network of neurons in the nervous system of a Zebrafish has won first prize at the Nikon Small World in Motion Awards, which highlight the best in photography and video captured through the microscope lens. We caught up with researchers behind the video to find out more.

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Chemists Design Novel One-Pot Reactions to Access Complex Natural Product Analogs for Drug Discovery
Chemists Design Novel One-Pot Reactions to Access Complex Natural Product Analogs for Drug Discovery
Article

Scientists have discovered powerful new reactions for the synthesis of nature-inspired privileged structures – one-pot, modular, elegantly designed chemical reactions that could minimize the gap between the chemical and biological space. Their study findings could be a turning point for the discovery of unmet diseases.

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Drug Screening: Cellular proliferation assay performed inside a mouse
Drug Screening: Cellular proliferation assay performed inside a mouse
Article

Although many new cellular assays entered the drug discovery scene over the course of the last decades, we still lack a predictable tool when it comes to selecting compounds or cell lines for xenograft testing. What is lacking?

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Emerging Classes of Next-generation Biotherapeutics
Emerging Classes of Next-generation Biotherapeutics
Article

We are entering uncharted territory in biopharmaceutical development. Emerging new classes of treatments are harnessing the natural power of viruses and cells and engineering them to fight human diseases. As our arsenal of conventional therapies begins to fail, a new army of biotherapeutics is on the horizon. Here, we look at two new classes of treatments leading the charge.

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