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Drug Discovery

Drug Discovery

ADME 101 Drug Transporter Studies: Lysosomal Trapping Webinar

This ADME 101 video discusses how compounds can become trapped by lysosomes, which can lead to high organ-to-blood ratios and mistaken for active drug transport, how concomitant administration of lysosomotropics could lead to elevated drug exposure levels, and how accumulation of lipophilic amines can lead to drug-induced phospholipidosis due to decreased phospholipid catabolism.

Microplate Improves Reproducibility of Immunocapture Assays

The Signum™ range of surface-active polystyrene microplates from Porvair Sciences set a new high standard for reproducible binding of hydrophobic and hydrophilic proteins.

Industry Insight

“Rewriting the Textbook” for Precision Medicine

Technology Networks recently had the pleasure of speaking with Mark Fidock, vice president for Diagnostic Development, Precision Medicine at AstraZeneca, to find out how the company is “rising to the challenge” of delivering precision medicines for chronic diseases.

Seamless Science for 3D Cell Models

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

Seamless Science for 3D Cell Models

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

Enzymes for Advancing Point-of-Care Diagnostics

Point-of-care testing is the future of diagnostic solutions. The main reason for this is point-of-care testing is robust, easy to use and provides immediate results and thus allows treatment decisions to be made more quickly. As an additional benefit, point-of-care diagnostic testing brings value to patients and healthcare systems.

We are here to help progress point-of-care diagnostics with our glycerol-free enzymes. Lyo-ready enzymes are as efficient and as high in performance as traditional formats of enzymes and this new formulation is suitable for use in microfluidics instruments.

COVID-19 Vaccination Linked With Temporary Increase in Menstrual Cycle Length

A large international study has confirmed the findings of a previous U.S. study that linked COVID-19 vaccination with an average increase in menstrual cycle length of less than one day.

A New Way To Identify “Safe Harbors” for Gene Therapies

Scientists have created a tool that can find safe places to introduce genes into human DNA. The tool is an early step in the process to improve the safety and efficacy of gene and cell therapies.

New Nanoparticle Could Protect Bones During Chemotherapy

Researchers have designed a cerium oxide nanoparticle — an artificial enzyme — that protects bones against damage from radiation. The nanoparticle has also shown abilities to improve bone regeneration, reduce loss of blood cells and help kill cancer cells.

Potential Drug Targets Could Prevent Antibiotic-Associated Hearing Loss

Researchers have identified multiple potential therapeutic targets for preventing hearing loss caused by aminoglycosides, a class of antibiotics.

mRNA Vaccines Protect Against Serious COVID-19 During Pregnancy

The first large, real-world study of the effectiveness of mRNA COVID-19 vaccines during pregnancy found these vaccines, especially two initial doses followed by a booster, are effective in protecting against serious disease in expectant mothers whether the shots are administered before or during pregnancy.

Mark a Course for the Future – Biomarkers in Cancer Immunotherapy

Here we explore how biomarkers are driving the immuno-oncology landscape. We dive into cutting-edge biomarker research and the challenges facing the field.

The “Streetlight Effect” in Proteomics

A bias exists within proteomics, where certain proteins are studied less frequently than others. In this article, we hear from Professor Kathryn Lilley on why some proteins attract less research attention, why this is problematic and how The Understudied Protein Initiative hopes to overcome it.

To Hallucinate or Not: The Big Questions Facing Psychedelics at FENS 2022

One sign that the tide around psychedelic science is changing is the decision by the organizers of the recent Federation of European Neuroscience Societies (FENS) conference, the largest such neuroscience event in Europe, to carve out a slot for this burgeoning area of research. Here's a summary of what went down.

CRISPR Screening: Studying Evolution in a Dish

CRISPR screening enables the rapid and unbiased identification of genes relevant to a specific biological pathway. In this article, we explore how researchers are using this cutting-edge tool to shape our understanding of biology and advance medicine.

Unlocking the Power of Precision Medicine – the Rheumatology Example

This article explores the potential for innovative diagnostics and a precision medicine approach to improve treatment for rheumatoid arthritis patients.

Reducing the Cost of Ownership of High-Performance Liquid Chromatography Systems

Personalized Medicine

Differentiating iPSCs – Which Approach Works Best?

Automation that Connects your Drug Discovery Workflow

Discovery of Novel Glutamine Antagonist Prodrugs: A Story from Bench 2 Bedside

Plant Virus Nanoparticles: New Applications for Developing Countries

How To Build an Effective Protein Degrader

This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and the questions you should ask yourself to ensure your final product will result in a complete protein degradation.

The Growing Importance of Mitochondrial Toxicity Assessment in Drug Discovery and Development

The pharmaceutical industry spent decades bringing several drugs to the market, only to be withdrawn due to liver failure, associated with mitochondrial toxicity. The tests available at the time could not detect this toxicity and drug developers were presented a market withdrawal risk.

Fundamentals of Flow Cytometry: The Five Stages To Consider for a Successful Flow Cytometry Experiment

Download this guide to discover tips on sample preparation, fluorescence, fluorochromes and your antigens, your cytometer and data analysis.

How to Future Proof Your Laboratory Informatics Environment

Download this guide to learn more about laboratory automation and the novel informatics solutions available to ensure sound and long-lasting investments.

Connecting Laboratories With Data-Driven Automation Software

Download this guide to learn more about automated software and the latest solutions available.

Webinars & Online Events

Fatbook: An Adipose-Tissue Immune Cell Social Network

Advances in Proteomics & Metabolomics 2022

Applied Versatility: Automated Liquid Handling for Many Applications

Ten Guidelines for Adopting Ontologies To Create FAIRer Scientific Data

Applications of Mass Spectrometry

Clinical Applications of Cell Therapy

Recent Advances in Gene Therapy

5 Unique Ways Organ-on-a-Chip Technology Is Being Applied in Biomedical R&D

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