We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

10 Things We Didn't Know Last Week – 10 May 2019

List

A wrap-up of the biggest science news from the last 7 days.

Read more

5 Specialized Techniques for Fragment-based Drug Discovery

List

In this list, we will discuss the principles of FBDD, how it compares to other drug discovery approaches, as well as highlighting various techniques that allow for lead compound identification with FBDD.

Read more

Reimagining Micro and Macro Chemical Workflows for Improved Communication

Webinar

Known as the “central science”, chemistry is essential to virtually all scientific disciplines.

Communicating information about millions of known, and even more unknown, chemical compounds, in an accurate, digestible, and elegant manner is essential to documenting the reproducibility and transparency of your research

Read more
Single-cell Analysis Opens Doors for Targeted Treatment in Autism Spectrum Disorder
News

Researchers have adopted single-cell analysis to uncover the molecular underpinnings of Autism Spectrum Disorder (ASD). Their findings may have implications for targeted therapeutics.

Read more

Broccoli Compound Restores Potent Cancer Cell Suppressor Function
News

Researchers report that indole-3-carbinol (I3C) – a natural compound found in broccoli – can be used to therapeutically target a gene (WWP1) known to play a role in several human cancers.

Read more

Progress in Priming Stem Cell Cardiomyocyte Maturation
News

Speeding up the transformation of induced pluripotent stem cells into cardiomyocytes is of interest for researchers involved in regenerative medicine, and drug development for cardiac diseases.

Read more

A Bite Out of the Blood-brain Barrier
News

Molecules from the immune system of a jawless parasitic fish could help lead the way to more effective treatments for multiple brain ailments, including cancer, trauma and stroke.



Read more

Smile for the Camera!
News

Scientists have developed a method with which an enzyme at work can be “photographed”, making it possible to better understand the function of important biomolecules.

Read more

Chip Platform a Tool for Modeling Drug Effects on Unborn Children
News

ETH researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process.

Read more

 
 
 
Antibodies in Research: The Good, the Bad, and the Validation Epidemic
Article

The specificity of antibody binding is incredibly important for many research disciplines, yet sourcing the best antibody for your research can be a challenge. This is partly because not all suppliers validate their antibodies sufficiently. How much of a problem is this?

Read more

Why Does Ketamine Fight Depression? Finding Answers at BNA 2019
Article

A significant minority of major depressive disorder patients don’t respond to currently available antidepressant medication. A newly approved treatment, based on the "club drug" ketamine, could change that. In a session at the British Neuroscience Association’s Festival of Neuroscience 2019, the potential mechanisms of ketamine’s antidepressant action were put under examination.

Read more

The Evolving Field of Cancer Biomarkers
Article

Given the complexity of cancer, it’s arguably unlikely that single molecules will work as clinically meaningful biomarkers for cancer. Today, biomarker discovery involves detecting patterns – characteristics or phenotypes that can be measured and monitored throughout a patient’s journey. Here, we look at two approaches being explored in this evolving field.

Read more

Sensitivity vs Specificity
Article

When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results you are obtaining are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow you to evaluate just that.

Read more

A Further Dimension to Drug Discovery: Combining 3D Culture With iPSCs
Article

Running in parallel with advances in 3D cell culture is the growing use of human cells derived from induced pluripotent stem cells. Researchers are interested in testing drugs in the most physiologically relevant models possible, so it was only a matter of time before these two approaches converged – providing optimized systems for disease modeling and drug toxicity testing.

Read more

Preclinical Modeling of Tumor Metastasis and Resistance: Current Challenges and New Approaches
Article

To improve cancer survival rates, pharma and biotech researchers must develop safe and effective therapies to treat not only primary tumors, but also metastatic growths and tumors that have acquired resistance.

Read more