PerkinElmer VICTOR Nivo Multimode Plate Reader - So Much Science So Little Bench Space

Video

The VICTOR Nivo system: The next big thing in plate readers is now the smallest.

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LC-MS/MS for Bioanalytical Peptide and Protein Quantification: MS Considerations

Video

Caitlin Dunning, Associate Scientist, discusses how to use mass spectrometry to develop sensitive, selective, and robust quantification methods for peptide and protein quantification, including: basic mass spectrometry considerations, MS tuning, and best practices for success.

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Advances in Fragment-Based Drug Discovery

Article

Over the past decade, fragment-based drug discovery has garnered increasing interest among drug discovery experts and has established itself as a key approach within the field – acting as an alternative starting point for the discovery of high-quality lead candidates. This article discusses the evolution of FBDD, highlights key drug discoveries, and explores the advantages and challenges of harnessing this approach

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Compound as Effective as FDA-Approved Drugs Against Life-Threatening Infections

Compound as Effective as FDA-Approved Drugs Against Life-Threatening Infections

News

Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.

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Bogong Moths Use Magnetic Fields to Navigate
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have found that the moths, like migratory birds, depend on the Earth's magnetic field to guide them on their way.

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Simple Sugar Prevents Neurodegeneration in Lysosomal Storage Disease
News

New therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB)

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Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass Spec
News

Benjamin A.Garcia, PhD, an expert in quantitative proteomics and Presidential Professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry.

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Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells

Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells

Article

Although cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.

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Food Safety Warnings Are Making Eating More Dangerous
Article

Food hazard warnings are making eating more dangerous

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Exploiting the Glycome for Cancer Therapeutics
Article

The surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.

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Scientists Explore the Molecular Mechanics that Drive us to Sleep
Article

Scientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles

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