What are the biggest challenges in drug discovery?

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We hear from the experts as they tell us their thoughts on the biggest challenges faced in drug discovery.

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Positive Allosteric Modulator Improves Neurodegenerative Outcomes

News

Global collaboration shows positive allosteric modulation of M1 Muscarinic receptors slows prion neurodegeneration and restores memory loss.

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Kinase Profiling Trends 2016

Article

Learn about current practices and preferences in kinase profiling, and understand future user requirements, particularly with respect to the cost and use of outsourced services.

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Disrupted GPS In Alzheimer's Linked To Tau Pathology In Entorhinal Cortex

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Pathological Tau kills excitatory neurons on entorhinal cortex leading to misalignment of grid fields and deterioration of spatial cognition.

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Immunotherapies Transfer-in To The Brain

Immunotherapies Transfer-in To The Brain

Researchers from Uppsala University have exploited the Transferrin receptor to overcome the blood brain barrier. 100-fold increase in antibody penetrance opens up new avenues for immunotherapeutic treatment of brain diseases.

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Immunoprofiler Iniative Launched By UCSF And Pharma

University of California San Francisco will partner with AbbVie, Amgen and Bristol Myers Squibb to analyse at least 500 tumour samples for immunologically relevant characteristics.

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RNA Hitches A Ride On Ultrasound Waves

Technique enables rapid delivery of RNA to treat colon inflammation.

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Making Strides in Sickle Cell Disease Research

The world's largest sickle stem cell disease library will contain a diverse range of samples that can be used to study the disease and develop therapeutics.

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