Latest Application Notes

A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity

Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.

Surface plasmon resonance (SPR) is a core technology used in many pharma and biotechnology settings for this purpose, however traditional initial SPR screening of weak affinity compounds using a single fixed concentration injection can present numerous challenges.

Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.

In recent years, interest in lipid nanoparticle (LNP) research has increased due to promising opportunities for RNA-based therapy and gene-editing technology, and LNPs are showing promise as nucleic acid delivery vehicles in the pharmaceutical industry.

Cell painting is a powerful phenotypic screening method used to gain a deeper understanding of the effects of chemical and genetic perturbagens on cells.

For therapeutic applications, it is important that protein production from mammalian cell lines is efficient and pure.

Download this app note to discover how patch-clamp can be used as part of an integrated risk assessment in first-in-human studies as well as later stages of clinical development.

Download this free application focus to learn more about how Agilent's latest RapidFire 400 mass spectrometry system.

During pharmaceutical development and manufacturing, there is always the question: are you following methods for current good laboratory practice or current good manufacturing practice?

Download this app note to discover how you can overcome challenges such as maintaining the shape and size of spheroids to reduce variability.