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Latest Application Notes

Application Note

Get a High-Resolution View of Your Lipid Nanoparticles

Lipid nanoparticles (LNP) play a key role in effectively protecting and transporting mRNA to target cells in mRNA-based vaccines and therapeutics. To ensure the quality and safety of LNP, lipid components and associated impurities/degradants need to be carefully characterized in raw materials and formulation.
Application Note

Label-Free, Real-Time Live Cell Assays for 3D Organoids

To successfully use these models across a variety of research disciplines and applications, approaches that reduce variability and technology pipelines to image and quantify these complex cell models are required.
Application Note

Cell Viability Assays - Which One Is Best Suited for My Application?

Download this app note to discover a microplate reader that covers a broad range of cell viability assay readouts, provides high sensitivity and full flexibility and offers a fast and easy assay setup.
Application Note

Is This Europe’s Most Modern Biobank?

The University of Szeged is one of Hungary’s leading research institutions with a long history of pioneering scientific achievements. For generations, the university’s scholars have been focused on collecting and storing biological samples for educational purposes as well as for clinical, biomedical and physiological research.
Application Note

Deep Learning-Based Image Analysis for Label-Free Monitoring of iPSC and 3D Organoid Cultures

Complex 3D biological models such as organoids and patient-derived spheroids are gaining popularity in many biomedical research areas because they more closely recapitulate in vivo tissues.
Application Note

Rapid and Reproducible Parallel Processing of Charge Heterogeneity Analysis of Protein Therapeutics

Rapid characterization of protein therapeutic charge variants can be challenging for the growing number and wider variety of new modality drug candidates. Automated capillary electrophoresis instruments offer fast separation times and high reproducibility for capillary isoelectric focusing.
Application Note

Genome Integrity Analysis of Adeno-Associated Viruses (AAV) Using Multi-Capillary Gel Electrophoresis

An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.
Application Note

Acceleration of Method Optimization for AAV Capsid Purity Analysis

The purity of adeno-associated virus (AAV) capsid proteins has important implications for efficacy of the viral vector. A robust analytical method for assessment of the capsid purity for a range of serotypes that can provide reliable results in a timely fashion is desirable.
Application Note

High-Throughput Multi-Capillary SDS Gel Electrophoresis of Proteins

Automated capillary electrophoresis instruments offer fast separation times and proven, high reproducibility for capillary sodium dodecyl sulfate gel electrophoresis (SDS-CGE), thus representing an excellent tool for the analysis of therapeutic proteins.
Application Note

Microscale Separation: A Chromatography System for Low Volume Size Exclusion Chromatography

The structural characterization of complex proteins gives researchers a glimpse into their in vivo mechanistic functions and complex chemistries. In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics.
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