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Latest Application Notes
Automated Online Card Extraction LC/MS System for the Determination of Clozapine and its Metabolites in Rat Blood
Application Note

Automated Online Card Extraction LC/MS System for the Determination of Clozapine and its Metabolites in Rat Blood

This application note describes the development and validation of a method on the AACE LC/MS system for the online analysis of DBS cards for the quantitation of clozapine and two of its metabolites in rat whole blood.
Automation of a Generic Fluorescent Methyltransferase Activity Assay
Application Note

Automation of a Generic Fluorescent Methyltransferase Activity Assay

The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.
Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Application Note

Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach

The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.
Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Application Note

Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates

This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.
Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Application Note

Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®

This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.
Kv1.5 Potassium Channel Assay Using the IonWorks HT System
Application Note

Kv1.5 Potassium Channel Assay Using the IonWorks HT System

This application note describes the use of the IonWorks HT Platform with a voltagedependent potassium channel Kv1.5.
Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System
Application Note

Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System

Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Application Note

Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Application Note

Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Recording of ICRAC in RBL-1 Cells on the PatchXpress 7000A Automated Patch Clamp System
Application Note

Recording of ICRAC in RBL-1 Cells on the PatchXpress 7000A Automated Patch Clamp System

Calcium release-activated calcium (CRAC) channels play an important role in intracellular Ca2+ homeostasis. Like other store-operated calcium channels, currents through the CRAC channel (ICRAC) are activated by depletion of calcium in the endoplasmic reticulum (ER) and serve the purpose of slowly replenishing the ER with Ca2+.
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