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Latest Application Notes

Application Note

Simultaneously Reducing your API Cost of Goods and Carbon Footprint

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Application Note

Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library

Here we demonstrate the detection of GLP-1R binding through the incorporation of a homogeneous cell-based binding assay using HTRF Tag-lite® technology.
Application Note

Automated High Throughput Functional Cell-based Bioassays for EGFR Blocking Antibodies

This study describes a novel, target-specific, cell-based assay platform that can be used to detect and differentiate potential inhibitors of Epidermal Growth Factor receptors.
Application Note

Automated Online Card Extraction LC/MS System for the Determination of Clozapine and its Metabolites in Rat Blood

This application note describes the development and validation of a method on the AACE LC/MS system for the online analysis of DBS cards for the quantitation of clozapine and two of its metabolites in rat whole blood.
Application Note

Automation of a Generic Fluorescent Methyltransferase Activity Assay

The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.
Application Note

Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach

The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.
Application Note

Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates

This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.
Application Note

Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®

This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.
Application Note

Kv1.5 Potassium Channel Assay Using the IonWorks HT System

This application note describes the use of the IonWorks HT Platform with a voltagedependent potassium channel Kv1.5.
Application Note

Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System

Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.
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