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Latest Application Notes
Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes
Application Note

Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes

In this application note the antimicrobial properties of the Thermo Scientific Finnpipette F1 were compared to traditional pipettes without antimicrobial treatment. The experiments were performed by an independent laboratory (Institut für Biotechnische Forschung und Entwicklung Graf GmbH, Kirkel-Limbach, Germany).
Reproducible Dispensing of Live Cells with the Thermo Scientific Multidrop Combi Reagent Dispenser
Application Note

Reproducible Dispensing of Live Cells with the Thermo Scientific Multidrop Combi Reagent Dispenser

High throughput cell-based assays are an important part of drug screening, and successfully dispensing viable cells is a key step in the process. Automated reagent dispensers are used to achieve higher throughput in the screening laboratories. Dispense must not only be quick, it must also be gentle enough to ensure cell viability.
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Application Note

Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)

During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Application Note

Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves

This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.
Characterization of Emission Properties of Aequorin Mutants with Rapid, High Throughput Screening Assay
Application Note

Characterization of Emission Properties of Aequorin Mutants with Rapid, High Throughput Screening Assay

This application note explains how to perform a rapid, high throughput screening assay of mutated photoprotein aequorin in order to find clones with more intense, slower kinetic, narrow spectral or color-shifted bioluminescent emission. Several examples of bioluminescent emission kinetics and spectra of mutated aequorins are included.
Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader
Application Note

Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader

Two cell-based signaling assays from Invitrogen, Fluo-4 Direct™ Calcium Assay and Tango™-bla U2OS GPCR Assay, were performed on the PHERAstar FS HTS instrument. The PHERAstar FS has several unique features that enhance the performance of these assays including direct optic bottom reading, high resolution cell layer scanning, injection at the point of measurement and dual emission detection.
Automated Turnkey Solubility and Permeability Assays
Application Note

Automated Turnkey Solubility and Permeability Assays

Millipore Corporation and Molecular Devices have partnered to provide platforms for solubility and permeability screening. The objective is to create automation-compatible 96- and 384-based systems with pre-validated methods, devices and analysis that can be run manually or in conjunction with standard laboratory automation.
Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase
Application Note

Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase

Pseudomonas elastase (LasB) is a key drug target in various chronic and intractable infections. A library of 160 potential, in-house synthesised, elastase inhibitors were screened using a fluorescence assay with the internally quenched substrate Abz-Ala-Gly-Leu-Ala-Nba. Enzymatic kinetic measurements were done on a FLUOstar OPTIMA and Km and Vmax values were calculated for each inhibitor using the MARS Data Analysis software.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
Application Note

Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader
Application Note

Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader

Two cell-based signaling assays from Invitrogen, Fluo-4 Direct™ Calcium Assay and Tango™-bla U2OS GPCR Assay, were performed on the PHERAstar FS HTS instrument. The PHERAstar FS has several unique features that enhance the performance of these assays including direct optic bottom reading, high resolution cell layer scanning, injection at the point of measurement and dual emission detection.
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