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Latest Application Notes

Application Note

An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega

G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
Application Note

A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition

Pgp expression has been linked to the effl ux of chemotherapeutic
drugs in human cancers leading to multidrug resistance. Pgp
activity can also result in low oral absorption and poor brain
penetration. Interaction of drugs with the Pgp may also cause
an increase in toxicity of co-administered compounds.
Application Note

Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology

This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Application Note

Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System

In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Application Note

Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay

Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Application Note

LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader

LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Application Note

Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays

When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Application Note

Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex

The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Application Note

Turbidometric Growth Curve Measurements and Liquid Evaporation Studies with a Microplate Photometer

The turbidity of a liquid sample is traditionally measured either with a nephelometer or a photometer. The measure of turbidity (also called optical density, OD) refers to the scattering of light from the particles of the measured sample. When measuring turbidity of a bacterial culture, the amount of scattered light is directly proportional to the number of bacterial cells in the sample.
Application Note

High Sensitivity ELISA Assays for the Detection of Melamine Residuals in Milk

Melamine is an industrial chemical most commonly used as a fire retardant in dry powder extinguishers due to its release of nitrogen gas when burned or charred. Melamine has been used illegally by adding it to food products in order to increase the apparent protein content.
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