Latest App Notes & Case Studies
App Note / Case Study
Polyol-Induced Increases in Thermal Stability of Antibodies by DSC
The goal of the study was to understand how the size of a polyol and orientation of the hydroxyl group influence the amount of thermal stability that could be induced upon seven monoclonal antibodies of different isotypes.
App Note / Case Study
The Application of MicroCal VP Capillary DSC at a Contract Development Organization
In this application note we describe a systematic approach to preformulation development that leverages biophysical characterization and standard analytics in the context of statistical design with the goal of shortening the pharmaceutical development cycle while improving the quality of the development studies.
App Note / Case Study
Cells in Double Emulsions for FACS Sorting
Capturing individual cells in 30 µm double emulsions,suitable for FACS sorting.
App Note / Case Study
Measuring The Particle Size Of Small Sample Volumes Using Laser Diffraction
App Note / Case Study
How Malvern Microcal ITC Adds Value In Drug Discovery With Applications From Assay Development To Lead Optimization
App Note / Case Study
Determining the Fluorescence Limit of Detection for a Given Flourophore
This note works through an experiment to approximately establish a
baseline in terms of the fluorescence limit of detection for a given fluorophore.
App Note / Case Study
Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis
In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
App Note / Case Study
Measuring Small Quantities of Dry Powder Using the Aero S and Mastersizer 3000
In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials with good reproducibility and illustrating the dispersion abilities of the Aero S.
App Note / Case Study
Drug Product Identification Using Handheld Raman
Handheld Raman spectroscopy is well accepted as a technique for raw material and excipient identification within the pharmaceutical industry. Using the correct Raman excitation wavelength can extend its capabilities into the areas of drug substance and drug product identification.
App Note / Case Study
The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability
This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
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